Responses to the first item in the Atrial Fibrillation Effect on Quality of Life instrument.
eFigure 1: Overall CABANA Trial CONSORT Diagram
eTable 1: Data Collection in the CABANA Trial Quality of Life Study
eTable 2: AFEQT Component Scores: Symptoms, Daily Activities, and Treatment Concern
eTable 3: Duke Activity Status Score
eTable 4: SF-36 Scores
eTable 5: Toronto Atrial Fibrillation Severity Score (AFSS) Scores
eTable 6: EQ-5D Scores
eTable 7: Stanford Presenteeism Scale (SPS-6) Scores
eTable 8: Work Productivity And Impairment (WPAI) Scores
eTable 9: AFEQT Scores in the 6-month Per Protocol Analysis
eTable 10: AFEQT Scores in the 3-month Per Protocol Analysis
eTable 11: AFEQT Scores in the 12-month Per Protocol Analysis
eTable 12: MAFSI Scores in the 6-month Per Protocol Analysis
eTable 13: MAFSI Scores in the 3-month Per Protocol Analysis
eTable 14: MAFSI Scores in the 12-month Per Protocol Analysis
eTable 15: AFEQT Scores with Adjustment for Site and the Site-Treatment Interaction as Random Effects
eFigure 2: AFEQT Summary Scores in Pre-Specified Subgroups by Intention-to-Treat
eFigure 3: MAFSI Frequency Scores in Pre-Specified Subgroups by Intention-to-Treat
eFigure 4: AFEQT Summary Scores in the 6-Month Per Protocol Analysis
eFigure 5: MAFSI Frequency Scores in the 6-Month Per Protocol Analysis
eFigure 6: AFEQT Scores by Baseline Tertiles by Intention-to-Treat
eFigure 7: MAFSI Scores by Baseline Tertiles by Intention-to-Treat
eFigure 8: AFEQT Summary Scores Illustrative Changes
eFigure 9: AFEQT Summary Score Responder Analysis
eFigure 10: MAFSI Frequency Score Responder Analysis
Statistical analysis plan
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Mark DB, Anstrom KJ, Sheng S, et al. Effect of Catheter Ablation vs Medical Therapy on Quality of Life Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial. JAMA. 2019;321(13):1275–1285. doi:10.1001/jama.2019.0692
What is the effect of catheter ablation, compared with medical therapy, on quality of life in patients with symptomatic atrial fibrillation?
In this randomized trial of 2204 patients with atrial fibrillation, catheter ablation, compared with conventional medical therapy, significantly improved quality of life at 1 year as measured by the Atrial Fibrillation Effect on Quality of Life score (mean between-group difference, 5.2 points; patient-level clinically important difference, ≥5 points) and the Mayo AF-Specific Symptom Inventory frequency score (mean between-group difference, −1.7 points; patient-level clinically important difference, ≤−1.6 points) and severity score (mean between-group difference, −1.5 points; patient-level clinically important difference, ≤−1.3 points).
In patients with symptomatic atrial fibrillation, catheter ablation, compared with medical therapy, led to clinically important and significant improvements in quality of life at 12 months.
Catheter ablation is more effective than drug therapy in restoring sinus rhythm in patients with atrial fibrillation (AF), but its incremental effect on long-term quality of life (QOL) is uncertain.
To determine whether catheter ablation is more beneficial than conventional drug therapy for improving QOL in patients with AF.
Design, Setting, and Participants
An open-label randomized clinical trial of catheter ablation vs drug therapy in 2204 symptomatic patients with AF older than 65 years or 65 years or younger with at least 1 risk factor for stroke. Patients were enrolled from November 2009 to April 2016 from 126 centers in 10 countries. Follow-up ended in December 2017.
Pulmonary vein isolation, with additional ablation procedures at the discretion of the investigators, for the catheter ablation group (n = 1108) and standard rhythm and/or rate-control drugs selected and managed by investigators for the drug therapy group (n = 1096).
Main Outcomes and Measures
Prespecified co-primary QOL end points at 12 months, including the Atrial Fibrillation Effect on Quality of Life (AFEQT) summary score (range, 0-100; 0 indicates complete disability and 100 indicates no disability; patient-level clinically important difference, ≥5 points) and the Mayo AF-Specific Symptom Inventory (MAFSI) frequency score (range, 0-40; 0 indicates no symptoms and 40 indicates the most severe symptoms; patient-level clinically important difference, ≤−1.6 points) and severity score (range, 0-30; 0 indicates no symptoms and 30 indicates the most severe symptoms; patient-level clinically important difference, ≤−1.3 points).
Among 2204 randomized patients (median age, 68 years; 1385 patients [63%] were men, 946 [43%] had paroxysmal AF, and 1256 [57%] had persistent AF), the median follow-up was 48.5 months, and 1968 (89%) completed the trial. The mean AFEQT summary score was more favorable in the catheter ablation group than the drug therapy group at 12 months (86.4 points vs 80.9 points) (adjusted difference, 5.3 points [95% CI, 3.7-6.9]; P < .001). The mean MAFSI frequency score was more favorable for the catheter ablation group than the drug therapy group at 12 months (6.4 points vs 8.1 points) (adjusted difference, −1.7 points [95% CI, −2.3 to −1.2]; P < .001) and the mean MAFSI severity score was more favorable for the catheter ablation group than the drug therapy group at 12 months (5.0 points vs 6.5 points) (adjusted difference, −1.5 points [95% CI, −2.0 to −1.1]; P < .001).
Conclusions and Relevance
Among patients with symptomatic atrial fibrillation, catheter ablation, compared with medical therapy, led to clinically important and significant improvements in quality of life at 12 months. These findings can help guide decisions regarding management of atrial fibrillation.
ClinicalTrials.gov Identifier: NCT00911508
Catheter ablation for atrial fibrillation (AF) was introduced clinically in the 1990s as a last-resort therapy for patients with drug-refractory symptomatic disease.1,2 Over the next 20 years, ablation evolved into a therapeutic option for a broader spectrum of patients with AF. This evolution was due to several important factors, including the achievement of high rates of successful remission of AF, the identification of the importance of pulmonary vein isolation to the success of the procedure, the decrease in complication rates among the higher volume centers, and the growing dissatisfaction with the lack of effective pharmacologic management options for AF rhythm control.3-6 While the earliest reports speculated that the procedure might be curative,1,5,7 additional experience showed that a substantial minority of patients who underwent ablation experienced recurrent AF if followed up carefully for long enough periods.
As the possibility of a permanent cure for AF with catheter ablation grew less certain, attention turned to the benefits of ablation on quality of life (QOL) associated with AF.8 Some of the early trials that examined the effects of catheter ablation on patients with AF found that ablation was more effective than drug therapy in improving QOL.3,4,9,10 However, these early studies were limited by relatively small sample sizes, a narrow spectrum of patients with AF enrolled (mostly patients with paroxysmal AF), and short duration of follow-up (typically ≤1 year). Hence, the magnitude of QOL benefits provided by ablation across the spectrum of treated participants with AF and the durability of those benefits remain incompletely defined.
The Catheter Ablation vs Antiarrhythmic Drug Therapy for Atrial Fibrillation (CABANA) trial began enrollment in 2009 to test the hypothesis that ablative therapy for AF is more effective than state-of-the-art drug therapies in a broad population of symptomatic but inadequately treated participants with AF. The primary study outcome, a composite measure of death, disabling stroke, serious bleeding, or cardiac arrest, is reported in an accompanying article.11 Comparison of long-term QOL outcomes was a major secondary objective of the CABANA research program and is the subject of this article.
Between November 2009 and April 2016, 2204 symptomatic patients with new-onset or undertreated paroxysmal, persistent, or longstanding persistent AF were enrolled at 126 clinical sites in 10 countries. Patients were older than 65 years or 65 years or younger with at least 1 risk factor for stroke. The primary study outcome was a composite measure of death, disabling stroke, serious bleeding, or cardiac arrest. Details of the trial design have been published,12 and the trial organization, CONSORT diagram (eFigure 1 in Supplement 1), and statistical analysis plan (Supplement 2) are provided. All patients provided written informed consent, and study protocol approval was obtained from each site’s institutional review board or ethics committee. Race and ethnicity data were collected as a standard component of a clinical trial supported by the National Institutes of Health (NIH), and the assignment of race/ethnicity was made by the site investigator in conjunction with the patient using standard NIH categories.
Patients were randomized to receive either catheter ablation (pulmonary vein isolation with additional ablation procedures at the discretion of the investigator) or drug therapy (rhythm or rate control, according to investigator discretion) using permuted block design with variable block size (between 2 and 4) stratified by clinical site.
The scores of 2 QOL measures were prespecified as co-primary end points: the Atrial Fibrillation Effect on Quality of Life (AFEQT) questionnaire and the Mayo AF-Specific Symptom Inventory (MAFSI). The AFEQT13 is a 21-item, AF-specific, health-related QOL questionnaire designed to assess the effect of AF on patient QOL. The AFEQT produces a summary score (calculated from 18 of the questions) and subscale scores in the following 3 domains: symptoms, daily activities, and treatment concern. Summary and subscale scores range from 0 (complete AF-related disability) to 100 (no AF-related disability). The first AFEQT item (“Are you currently in AF?”) is not included in the scoring. Two additional items regarding treatment satisfaction are not included in the summary score and were not collected for this trial. For AFEQT scales, a score of 5 or more has been identified as a benchmark for a clinically meaningful change in an individual patient.14
The MAFSI was developed as a modification and update of the Bubien-Kay Symptom Checklist.15 A modified MAFSI8 questionnaire, comprised of a 10-item AF symptom checklist that asked about both the frequency and severity of each symptom, was used in this trial. The questionnaire asked participants to indicate the frequency of symptoms over the past month as 0 (never), 1 (rarely), 2 (sometimes), 3 (often), or 4 (always). Item responses were added together for a total frequency score that ranged from 0 (no AF symptoms) to 40 (the most severe AF symptoms). MAFSI severity scores over the past month were recorded as 1 (mild), 2 (moderate), or 3 (extreme). Items were then added together to produce the total severity score, which ranged from 0 (no AF symptoms) to 30 (the most severe AF symptoms). For an individual patient, a clinically meaningful change in the MAFSI score has not previously been established and therefore was considered 1.6 points for the frequency score and 1.3 points for the severity score (approximately one-fourth of the pooled baseline SD).10 MAFSI scores were collected on the trial case report form, which was administered by site coordinators at all follow-up points.
Additional QOL instruments used to assess cardiac and health status domains included the Duke Activity Status Index (DASI),16 the Atrial Fibrillation Severity Scale (AFSS),17 the 36-item Short Form Survey (SF-36),18 and the EQ-5D 3 level version (EQ-5D-3L).19 Baseline and follow-up assessments also included the patient’s employment status. For patients who were working, responses to the Stanford Presenteeism Scale20 and the Work Productivity and Activity Impairment Questionnaire21 were collected to evaluate the effect of catheter ablation on the patient’s ability to work. Additional descriptions of these instruments are provided in Supplement 1.
QOL data were collected via structured interviews at randomization and at months 3 and 12, then every 12 months thereafter (or at the last follow-up visit for participants who prematurely withdrew from the study). A subset of the QOL assessments that included a sampling of questions from the AFEQT, MAFSI, AFSS, SF-36, EQ-5D-3L, Stanford Presenteeism Scale, and Work Productivity and Activity Impairment Questionnaire was also collected at month 6 and every 12 months thereafter. Site coordinators were trained by Duke Clinical Research Institute (DCRI) personnel to perform structured QOL interviews. All baseline interviews were performed by site coordinators. Trained interviewers from the DCRI’s Outcomes Research Group, who were masked to treatment assignment, conducted follow-up interviews via telephone for North American sites. Site coordinators conducted follow-up interviews for sites outside North America.
All primary analyses were performed with treatment groups defined by the principle of intention-to-treat (ITT) analyses (as randomized). Descriptive statistics were presented as percentages for discrete variables and median and 25th and 75th percentiles or mean and SD for continuous variables.
The AFEQT and MAFSI end points were analyzed using a repeated-measures mixed model with baseline score and month 3, 12, 24, 36, 48, and 60 responses included as outcome variables, and time, treatment, and time × treatment as fixed effects. Restricted maximum likelihood estimation with an unstructured covariance matrix and Kenward-Roger degrees of freedom approximation was used to model all available data from each patient. No formal imputation procedures were used in our analyses because the mixed-effects model does not require complete data or the same length of follow-up for each patient.
Point estimates for each treatment group and treatment group mean differences (catheter ablation group score − drug therapy group score) with 95% CIs were generated for each follow-up point. The possibility of spurious statistical testing results due to multiple comparisons was addressed in 2 ways. First, the number of formal statistical tests in this report was limited. Two-sided P values are provided for the prespecified co-primary treatment comparisons at 12 months, for the same end points averaged across all follow-up assessments, and for the tests of treatment × covariable interactions. Second, the primary treatment comparison to be tested statistically was prespecified to be the between-treatment group differences at month 12 for the co-primary QOL end points. Where P values are provided as interpretive aids, significance, understood as a heuristic of unexpectedness regarding the consistency of the data with the null hypothesis, was defined as P < .05.22
Secondary analyses examined the treatment effects at months 3, 24, 36, 48, and 60 as well as averaged across the 6 follow-up points to provide an overall mean estimate of effect size. Unadjusted data were displayed as histograms and adjusted data as subgroup plots. The estimated differences and 95% CIs were obtained using the ESTIMATE statement in SAS PROC MIXED software. The 95% CIs around the treatment effect size estimates were used to gauge precision.22 A clinically meaningful difference at the individual patient level refers to a change that patients would both notice and consider important or worthwhile. There are no fully suitable benchmarks for assessing the incremental clinically meaningful differences at the treatment group level.23 Therefore, the patient-level benchmark was used as an informal treatment effect benchmark.
QOL outcomes were compared for the subgroups that were prespecified in the overall trial analysis.12 Baseline tertiles of AFEQT and MAFSI scores for post hoc subgroup analyses were also examined, because the potential to demonstrate a large QOL treatment benefit has been shown in other contexts to be dependent, to an important extent, on the baseline level of impairment present.10 Subgroup treatment effect sizes, CIs, and P values were generated using the ESTIMATE statement in SAS PROC MIXED software and included an interaction between treatment and subgroup and a 3-way interaction among treatment, subgroup, and interval.
Per-protocol analyses were performed following the methods established for the clinical analyses of the trial.11 Patients had to undergo ablation within 3 months, 6 months, or 12 months following randomization to be counted as following the ablation protocol. The drug therapy protocol consisted of all patients randomized to the drug therapy group. Patients who crossed over to the catheter ablation group were censored at the time of crossover.
To provide a more clinically intuitive sense of the treatment effect at 12 months, we conducted 2 additional post hoc analyses. One analysis examined patterns of QOL scores at baseline and 12 months by severity levels, and the second was a responder analysis. For the severity subgroup analysis, the AFEQT scores at baseline and 12 months were divided into categories corresponding to severely symptomatic from AF (<70), mildly to moderately symptomatic from AF (70-89), or minimally symptomatic from AF or asymptomatic (≥90). For the responder analyses, we compared the proportion of patients in each treatment group whose 12-month AFEQT scores improved from baseline by at least 5, at least 10, at least 15, and at least 20 points, roughly corresponding to values representing from 0.25 SD to 1.0 SD of the baseline score. These comparisons were done using the baseline severity subgroup categories. The responder analysis for the MAFSI frequency score used baseline values of less than 4, 4 to 9, and greater than 9 to indicate minimally symptomatic, mildly to moderately symptomatic, and severely symptomatic from AF, respectively, and responder effect sizes ranging from 0.25 SD (improvement ≥1.6 points) to 1.0 SD (improvement ≥6.4 points).
Because the study was performed at multiple sites, we also performed a post hoc ITT mixed-model analysis adjusted for enrolling site and enrolling site × treatment group interaction as random effects.
All analyses were performed using SAS software, version 9.4 or later (SAS Institute).
The median age of the 2204 patients enrolled in the trial was 68 years, 1385 (62.8%) were men, 2025 (91.9%) were white, 946 (42.9%) had paroxysmal AF, and 1257 (57.1%) had persistent AF (Table 1). Median (25th, 75th percentiles) follow-up duration was 48.5 (29.9, 62.1) months. Of the 2204 patients, 1108 were randomized to the catheter ablation group and 1096 were randomized to the drug therapy group (eFigure 1 in Supplement 1).
Of a possible 20 461 patient QOL questionnaires from baseline through 60 months, 18 436 (90.1%) were collected. For the co-primary end points (AFEQT and MAFSI scores), data from at least 1 questionnaire at 12 months were collected from 1883 of 2074 possible questionnaires (90.8%). At month 60, data were collected from 711 of 897 possible questionnaires (79.3%). The number of expected questionnaires excluded questionnaires from patients who died or withdrew from the trial. The rate of expected but missing QOL questionnaires did not differ by treatment group at baseline or any follow-up interval (eTable 1 in Supplement 1).
At baseline, 915 of 1064 (86.0%) patients in the catheter ablation group and 885 of 1057 (83.7%) in the drug therapy group self-reported being in atrial fibrillation currently or within the past month (Figure 1). By month 12, this rate dropped to 195 of 926 (21.1%) in the catheter ablation group and 362 of 910 (39.8%) in the drug therapy group. At 60 months, 85 of 344 patients (24.7%) in the catheter ablation group and 117 of 334 patients (35.0%) in the drug therapy group reported AF within the past month.
The mean AFEQT summary score (range, 0-100; a higher score indicates a lower level of AF-related disability) baseline values were 62.9 points in the catheter ablation group and 63.1 points in the drug therapy group (Table 2 and Figure 2). At 12 months, the mean summary scores were 86.4 points in the catheter ablation group and 80.9 points in the drug therapy group. The mean AFEQT summary score difference at 12 months, favoring catheter ablation, was 5.3 points (95% CI, 3.7-6.9; P < .001). At the 5-year follow-up, the mean AFEQT summary score was 3.4 points higher in the catheter ablation group than in the drug therapy group (95% CI, 2.1-4.8; P < .001). All 3 component scores for the AFEQT (symptoms, daily activities, and treatment concern) showed comparable patterns of benefit in favor of catheter ablation (eTable 2 in Supplement 1).
The mean MAFSI frequency score (range, 0-40; a lower score indicates less frequent symptoms) values, based on ITT analysis, at baseline and 12 months were 11.8 points and 6.4 points, respectively, in the catheter ablation group and 11.9 points and 8.1 points, respectively, in the drug therapy group. The mean difference in MAFSI frequency scores at 12 months was −1.7 points, favoring catheter ablation (95% CI, −2.3 to −1.2; P < .001) (Table 2 and Figure 3). Among all follow-up intervals, the mean MAFSI frequency score difference was −1.4 points (95% CI, −1.9 to −0.9; P < .001). The mean MAFSI severity score (range, 0-30; a lower score indicates less severe symptoms) values, based on ITT analysis, at baseline and 12 months were 9.3 points and 5.0 points, respectively, in the catheter ablation group and 9.3 points and 6.5 points, respectively, in the drug therapy group. The mean MAFSI severity score difference at 12 months showed a higher level of improvement in the catheter ablation group compared with the drug therapy group (difference, −1.5 points [95% CI, −2.0 to −1.1]; P < .001) (Table 2). Among all follow-up intervals, the mean MAFSI severity score difference was −1.1 points (95% CI, −1.5 to −0.8).
Secondary QOL end points, including the DASI, SF-36 scales, AFSS, and the EQ-5D scores, showed the same general patterns of treatment difference seen with the AFEQT and MAFSI scores (eTables 3-6 in Supplement 1). At baseline, 35% of trial patients were employed. At 12 months, 32% of patients in the catheter ablation group and 34% of patients in the drug therapy group reported current employment. Additional employment and productivity measures are reported in eTable 7 and eTable 8 in Supplement 1.
In the AFEQT, there were no treatment × covariable interactions 12 months after randomization in the clinically prespecified subgroups (eFigure 2 in Supplement 1). In particular, there were no significant differences in treatment effect according to site location (only North America masked QOL follow-up, rest of the world unmasked QOL follow-up) (P = .23). For the MAFSI frequency score, there was a statistically significant interaction between treatment and the subgroup with hypertension and left ventricular hypertrophy (P = 0.02; eFigure 3 in Supplement 1). The magnitude of the difference in AFEQT scores for this subgroup interaction was proportionately smaller and not statistically significant.
A total of 102 of 1108 patients (9%) randomized to the catheter ablation group did not undergo the procedure, while 301 of 1092 patients (28%) randomized to the drug therapy group crossed over to catheter ablation at a median of 368 days.11 To explore the potential effects of patients who crossed over, a prespecified per-protocol analysis was performed, in which the catheter ablation group included the 969 patients who had the procedure within the first 6 months following randomization and the drug therapy group started with all patients randomized to receive drug therapy and censored patients who subsequently crossed over to catheter ablation at the time of crossover. Alternate time points (ie, 3 months and 12 months) were used to define the catheter ablation cohort but did not materially alter the results.
The 6-month per-protocol analysis (using a 6-month window from randomization to define a protocol catheter ablation procedure) showed a pattern of incremental treatment benefit in the catheter ablation group compared with the drug therapy group, based on mean AFEQT summary scores, that was evident at the 12-month follow-up (difference, 6.8 points [95% CI, 5.2-8.5]) and consistent at the 60-month follow-up (difference, 5.6 points [95% CI, 3.0-8.1]) (eTable 9 and eFigure 4 in Supplement 1). The 3-month and 12-month per-protocol analyses also showed similar treatment benefit for the catheter ablation group (eTables 10 and 11 in Supplement 1). A similar pattern of benefit favoring catheter ablation was seen in the 6-month per-protocol analysis based on mean MAFSI frequency scores at the 12-month follow-up (difference, −1.9 points [95% CI, −2.5 to −1.3]) and at the 60-month follow-up (difference, −1.8 points [95% CI, −2.8 to −0.9]) (eTable 12 and eFigure 5 in Supplement 1). The 3-month and 12-month per-protocol analyses showed similar results (eTable 13 and eTable 14 in Supplement 1).
The benefit of catheter ablation varied as a function of the baseline AFEQT score (eFigure 6 in Supplement 1). For patients in the lowest AFEQT tertile (score range, 0-55), the mean score in the catheter ablation group was 7.7 points higher than in the drug therapy group at 12 months (95% CI, 5.1-10.3), while the middle tertile (score range, 55.1-74) had an difference of 5.3 points (95% CI, 2.7-7.9), and the highest tertile (score range, 74.1-100) had the smallest difference (2.7 points [95% CI, 0.2-5.2]; P = .023). No consistent relationship was found between baseline MAFSI frequency score tertiles and 12-month catheter ablation treatment benefit (eFigure 7 in Supplement 1).
Of 2162 patients in both groups at baseline, 1302 (60%) were severely symptomatic, 655 (30%) were mildly to moderately symptomatic, and 205 (10%) were minimally symptomatic or asymptomatic, based on AFEQT responses. At 12 months, 11% more patients in the drug therapy group than the catheter ablation group were severely symptomatic and 14% more patients in the catheter ablation group than the drug therapy group were minimally symptomatic or asymptomatic (eFigure 8 in Supplement 1).
Responder analyses were used to examine the sensitivity of the treatment benefit from catheter ablation to the criteria used to define a clinically important difference in AFEQT and MAFSI scores. In patients whose baseline scores were in the severely symptomatic or mildly to moderately symptomatic categories, the incremental QOL benefits from ablation were not sensitive to the definition used to define a clinically important improvement (eFigure 9 and eFigure 10 in Supplement 1). The 205 of 2162 patients (10%) who had baseline scores in the minimally symptomatic category showed no difference by treatment group and the smallest improvements over the first 12 months of follow-up.
Adjustment for site and the site-treatment interaction as random effects had no effect on estimates of treatment effect (eTable 15 in Supplement 1).
In this international multicenter randomized trial, catheter ablation provided incremental symptomatic and QOL benefits over drug therapy that were clinically important and statistically significant for patients with AF. In addition to the incremental benefits produced by catheter ablation, patients in both treatment groups demonstrated clinically important improvements of approximately 20% to 50% in AF symptoms and QOL scores relative to baseline values.
A major secondary objective of the CABANA research program was to compare the effects of catheter ablation with drug therapy on long-term patient-reported outcomes in the 2204 patients with AF randomized in the trial. Interpretation of QOL data can be challenging because the measures used are often unfamiliar to both clinicians and patients.10,24 Interpretive benchmarks can be established for patient-level assessments but may not be suitable for treatment group–level comparisons in a clinical trial because the mean treatment difference can be achieved in several very different ways (eg, every patient in the catheter ablation group has the mean level of improvement, some patients have large improvements while others improve modestly or not at all).23 For both co-primary QOL end points in this study, the 12-month prespecified comparisons showed a mean treatment effect size for ablation that was equal to the patient-level benchmark, implying that a substantial proportion of patients had sizable, clinically important incremental improvements after catheter ablation relative to drug therapy.
For both MAFSI and AFEQT summary scores, treatment benefits from catheter ablation tended to be maximal at 12 months and showed some modest attenuation at or after 24 months. Similar patterns were seen for most of the secondary QOL instruments. At least 2 possible explanations for the smaller effect at later follow-up points are possible. One explanation is that more patients experienced recurrent AF at the time of the later study follow-up, which reduced some of the benefit of catheter ablation evident at 12 months. However, mean AFEQT scores in the catheter ablation group between 12 months and 60 months did not decrease. Instead, drug therapy group scores increased modestly over time. The second possibility, suggested by these patterns, is that patients who crossed over from the drug therapy group attenuated the benefits of the catheter ablation group. In support of this possible explanation, the per-protocol analysis comparison showed treatment differences that were slightly higher at 12 months than the ITT analysis comparisons, and the pattern of late attenuation was no longer evident.
Two sources of possible bias exist when QOL outcomes are measured in an unmasked trial. First, the patient may be biased in his or her self-assessments because of expectations tied to knowledge of the treatment received. To control for this possibility, sham or placebo treatment groups may be helpful. Sham AF ablation has not been attempted, to our knowledge, and its feasibility is uncertain. With regard to what can be done with currently available data to address this issue, future analyses are planned to examine the extent to which QOL changes after ablation are concordant with electrocardiographic monitoring of disease activity. Second, the outcome assessment process may be biased because of knowledge of treatment group assignments. In CABANA, QOL outcomes for North American patients were performed centrally by telephone interviewers at DCRI who were unaware of each patient’s treatment assignment. Assessments for patients outside of North America were done by local site coordinators who had access to treatment assignment information. No significant difference in the treatment effect size was seen according to a prespecified treatment × location interaction.
A number of previous trials have compared the effects of catheter ablation vs drug therapy on QOL in patients with AF. These studies varied in the type of AF that was examined, they were much smaller than CABANA, and they had much shorter follow-up.5,6 QOL was assessed in most trials with the SF-36 and a version of the Bubien-Kay Symptom Checklist.10 Most of these trials, but not all,4 found that ablation had a significant benefit on QOL in patients with AF.3,9
To make interpretation of the trial findings more clinically intuitive, 3 post hoc analyses were performed. First, defining subgroups of AFEQT scores by tertiles at baseline showed that the greater the extent of AF-related baseline impairment, as reflected in the AFEQT scores, the greater the incremental improvement provided by catheter ablation over drug therapy (eFigure 6 in Supplement 1). Second, defining interpretive categories for AFEQT showed that at baseline, 60% of patients in both groups were severely symptomatic, 30% were mildly to moderately symptomatic, and 10% were minimally symptomatic or asymptomatic (eFigure 8 in Supplement 1). At 12 months, 56% of patients in the catheter ablation group and 42% in the drug therapy group were minimally symptomatic or asymptomatic. Thus, the catheter ablation group produced 14% more patients who achieved complete or near-complete relief of their AF symptoms. In addition, responder analyses were conducted for both AFEQT and MAFSI scores, varying the size of the improvement required to define a clinically important difference from 0.25 SD to 1.0 SD, and found that the incremental benefits of ablation were robust even when a clinically important difference was defined conservatively (eFigure 9 and eFigure 10 in Supplement 1).
This study has several limitations. First, the treatment groups were not masked. Second, QOL studies often generate a multitude of possible comparisons because multiple instruments can be used, with each measured repeatedly over the course of study follow-up. A 3-part strategy was employed to ensure the results were robust: (1) 2 co-primary QOL end points (AFEQT and MAFSI scores) and 1 follow-up point (12 months) were prespecified to serve as the primary QOL statistical comparisons, (2) the effects of catheter ablation vs drug therapy on the AFEQT and MAFSI scores averaged over the 60-month follow-up period were compared to provide robust secondary statistical comparisons, and (3) all other comparisons of primary treatment effects were performed using estimates of adjusted effect size and precision (95% CIs) without P values. In those comparisons, consistency of patterns of treatment effects over time and across instruments was considered more important than individual time point comparisons that might meet criteria for statistical significance. Third, missing follow-up data create the potential for biased estimates of treatment effects. In large international trials, even with the exercise of great diligence, some amount of missingness is unavoidable when assessing nonfatal outcomes, particularly outcomes requiring the active participation of study participants. In the present study, 2 factors made serious biases due to missing QOL end point data very unlikely: (1) no differences were observed by treatment group in the rates of missing data up to 5 years, and (2) overall rates of follow-up co-primary end point QOL data collection were 91% at 12 months and 79% at 5 years, and results were stable over time.
Among patients with symptomatic atrial fibrillation, catheter ablation, compared with medical therapy, led to clinically important and significant improvements in quality of life at 12 months. These findings can help guide decisions regarding management of atrial fibrillation.
Accepted for Publication: February 14, 2019.
Corresponding Author: Daniel B. Mark, MD, MPH, Director, Outcomes Research, Duke Clinical Research Institute, 2400 Pratt St, Room 0311, Durham, NC 27705 (firstname.lastname@example.org).
Published Online: March 15, 2019. doi:10.1001/jama.2019.0692
Correction: This article was corrected on June 18, 2019, to correct an error in the Results section that stated that a higher Atrial Fibrillation Effect on Quality of Life score indicates a higher level of atrial fibrillation–related disability. The Results have been corrected and now state that a higher Atrial Fibrillation Effect on Quality of Life score indicates a lower level of atrial fibrillation–related disability.
Author Contributions: Drs Mark and Anstrom had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Mark, Anstrom, Monahan, Bahnson, Poole, Rosenberg, Lee, Packer.
Acquisition, analysis, or interpretation of data: Mark, Anstrom, Sheng, Piccini, Baloch, Daniels, Bahnson.
Drafting of the manuscript: Mark, Baloch, Daniels, Packer.
Critical revision of the manuscript for important intellectual content: Anstrom, Sheng, Piccini, Monahan, Daniels, Bahnson, Poole, Rosenberg, Lee, Packer.
Statistical analysis: Mark, Anstrom, Sheng, Lee.
Obtained funding: Mark, Lee, Packer.
Administrative, technical, or material support: Baloch, Monahan, Daniels, Rosenberg, Packer.
Supervision: Baloch, Monahan, Packer.
Conflict of Interest Disclosures: Dr Mark reported receiving grants from the National Institutes of Health (NIH) and Mayo Clinic during the conduct of the study; grants from Merck, Oxygen Therapeutics, Bristol-Myers Squibb, AstraZeneca, the University of Calgary, Eli Lilly & Company, AGA Medical, St Jude Medical, and Tufts University and personal fees from CeleCor and Novo Nordisk outside the submitted work. Dr Anstrom reported receiving grants from NIH during the conduct of the study. Dr Piccini reported receiving grants from ARCA biopharma, personal fees from Allergan, grants and personal fees from Abbott, grants from Boston Scientific, personal fees from Biotronik, grants from Gilead, personal fees from GlaxoSmithKline, grants from Janssen, personal fees from Medtronic, personal fees from Motif Bio, personal fees from Phillips, and personal fees from Sanofi outside the submitted work. Ms Monahan reported receiving grants from NIH, St Jude Foundation and Corporation, Biosense Webster Inc, Medtronic Inc, and Boston Scientific Corporation during the conduct of the study; providing consulting services to Biosense Webster Inc and providing consulting services to and receiving personal fees from Thermedical Inc outside the submitted work. Ms Daniels reported receiving grants from NIH and Mayo Clinic during the conduct of the study and personal fees from CeleCor outside the submitted work. Dr Bahnson reported receiving grants from NIH and Mayo Clinic during the conduct of the study; grants and personal fees and participating as a site primary investigator for a pivotal trial and receiving reimbursement from CardioFocus Inc, grants from Biosense Webster, grants from St Jude Medical, grants from Medtronic, and grants from Boston Scientific outside the submitted work; and a pending patent for a catheter/sheath for intracardiac imaging. Dr Poole reported receiving grants from Mayo Clinic during the conduct of the study and grants from AtriCure outside the submitted work. Dr Lee reported receiving grants from the National Heart, Lung, and Blood Institute (NHLBI) during the conduct of the study. Dr Packer reported receiving grants from NIH/NHLBI, St Jude Medical Corporation and Foundation, Biosense Webster Inc, Medtronic Inc, and Boston Scientific Corp during the conduct of the study; and receiving grants from Abbott, Biosense Webster Inc, Boston Scientific Corp, CardioFocus, Medtronic Inc, St Jude Medical, CardioInsight, NIH, Siemens, Thermedical, Endosense, Robertson Foundation, and Hansen Medical; serving on the advisory board without compensation for Abbott, Biosense Webster Inc, Boston Scientific Corp, CardioFocus, Medtronic Inc, St Jude Medical, Spectrum Dynamics, Siemens, Thermedical, Johnson & Johnson, and SigNum Preemptive Healthcare, Inc; speaking with honorarium from Biotronik and MediaSphere Medical, LLC; receiving royalties from Wiley & Sons, Oxford, and St Jude Medical; Dr Packer and Mayo Clinic jointly have equity in a privately held company, External Beam Ablation Medical Devices, outside the submitted work; Dr Packer has mapping technologies with royalties paid. No other disclosures were reported.
Funding/Support: Supported by grants U01HL89709, U01HL089786, U01HL089907 and U01HL089645 from the National Heart, Lung, and Blood Institute, St Jude Foundation and Corporation, Biosense Webster Inc, Medtronic Inc, Boston Scientific Corporation, and Mayo Clinic.
Role of the Funder/Sponsor: The National Heart, Lung, and Blood Institute was involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. St Jude Foundation and Corporation, Biosense Webster Inc, Medtronic Inc, Boston Scientific Corporation, and Mayo Clinic were not involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Group Information: The CABANA Investigators.
Executive Committee: Douglas L. Packer, MD, PI, Richard A. Robb, PhD, PI; Kristi H. Monahan, RN, Maryam E. Rettmann, PhD, Mayo Clinic, Rochester, MN; Kerry L. Lee, PhD PI, Daniel B. Mark, MD, MPH, PI, Tristram D. Bahnson, MD, Jonathan P. Piccini, MD, MHS, Beth Martinez, RN, Duke Clinical Research Institute, Duke University, Durham, NC; Jeanne E. Poole, MD, University of Washington Medical Center, Seattle, WA; Alice Mascette, MD, Yves Rosenberg, MD, MPH, Neal Jeffries, PhD, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD; L. Brent Mitchell, MD, Libin Cardiovascular Institute, Alberta Canada; Greg G. Flaker, MD, University of Missouri-Columbia, Columbia, MO.
Statistical and Data Coordinating Center: Kerry L. Lee, PhD, PI, Hussein R. Al-Khalidi, PhD, Tristram D. Bahnson, MD, Adam Silverstein, MS, Alicia Ellis, PhD, Beth Martinez, MS, PMP, Sheri A Ussery, RN, CCRA, Kathleen L. Moretz, RN, PMP, DCRI Clinical Operations Team, Duke Clinical Research Institute, Duke University, Durham, NC; Dr Sarah Hagen, International Clinical Operations Team, World Wide Clinical Trials, Berlin Germany.
Quality of Life Investigational Team: Daniel B. Mark, MD, MPH, PI, Kevin Anstrom, PhD, Khaula Baloch, MPH, Diane M. Liu, CTC, Janet Blount, Shubin Sheng PhD, Melanie R. Daniels, BA, DCRI Outcomes Call Center Staff and Interviewers, Duke Clinical Research Institute, Duke University, Durham, NC.
Economics Investigational Team: Daniel B. Mark, MD, MPH, PI, Patricia Cowper, PhD, Kevin Anstrom, PhD, David Knight, MS, Elizabeth F. O’Neal, BA, Melanie R. Daniels, BA, Duke Clinical Research Institute, Duke University, Durham, NC.
Image Analysis Investigational Lab: Richard A. Robb, PhD, PI, David R Holmes III, PhD, Maryam E. Rettmann, PhD, Jerome Breen, MD, Biomedical Imaging Resource Core, Mayo Clinic, Rochester, MN.
Steering Committee: L. Brent Mitchell, MD, Libin Cardiovascular Institute, Alberta, Canada; Greg G. Flaker, MD, University of Missouri-Columbia, Columbia, MO; David Wilber, MD, Loyola Medicine, Maywood, IL; James Reiffel, MD, Columbia University College of Physicians and Surgeons, New York, NY; Peter Kowey, MD, Lankenau Medical Center, Wynnewood, PA; Gerald Naccarelli, MD, Pennsylvania State Hershey Cardiovascular Institute, Hershey, PA; John P. DiMarco, MD, PhD, University of Virginia Health Sciences Center, Charlottesville, VA; D. Wyn Davies, MD, St Mary's Hospital, London, England UK; Riccardo Cappato MD, Milan, Italy; Jon M. Kalman, MD, PhD, Royal Melbourne Hospital, Parkville, Victoria Australia; Karl-Heinz Kuck, MD, Asklepios Klinik St George, Hamburg, Germany; Gerhardt Hindricks, MD, Herzzentrum Leipzig, Leipzig, Germany; Hugh Calkins, MD, Johns Hopkins University, Baltimore, MD; William G. Stevenson, MD, Brigham and Women’s Hospital, Boston, MA.
Data and Safety Monitoring Board: Alfred Buxton, MD (Chair), Beth Israel Deaconess Medical Center, Boston, MA; Anne B. Curtis, MD, University of Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; Barry R. Davis, MD, PhD, University of Texas School of Public Health, Houston, TX; Connie M. Ulrich, PhD, RN, FAAN, University of Pennsylvania School of Nursing, Philadelphia, PA; Ralph Lazzara, MD, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Terry Peters, PhD, Robarts Research Institute, London, Ontario Canada.
Clinical Events Committee: L. Brent Mitchell, MD (Chair), University of Calgary, Calgary, Alberta Canada; Jared T. Bunch, MD, Intermountain Medical Center, Murray UT; James Daubert, MD, Duke University, Durham, NC; Blair Halperin, MD, Providence St Vincent Medical Center/Portland, OR; John Holshouser, MD, The Sanger Clinic, PA/Charlotte, NC; Steven Kutalek, MD, Drexel University College of Medicine, Philadelphia, PA; Greg Michaud, MD, Vanderbilt University, Nashville, TN; Paul Mounsey, MD, University of North Carolina, Chapel Hill, NC; George Wyse, MD, Libin CV Institute/U of Calgary, Calgary, Alberta Canada.
Neurological (Stroke) Clinical Events Committee: Greg Flaker (Chair), MD, University of Missouri, Columbia, MO; Rodney Bell, MD, Thomas Jefferson University Hospital, Philadelphia, PA; Arnold Greenspon, MD, Thomas Jefferson University Hospital, Philadelphia, PA; William Logan, MD, Mercy Clinic, St Louis, MO; Pradeep Sahota, MD, Niranjan Singh, MD, University of Missouri-Columbia, Columbia, MO.
CABANA Innovative Ablation Therapy Committee: D. Wyn Davies, MD (Chair), St Mary’s Hospital London, England, United Kingdom; Hugh Calkins, MD, Johns Hopkins Hospital, Baltimore, MD; Richard Schilling, MD, Queen Mary, University of London, England, United Kingdom; Atul Verma, MD, Newmarket Cardiology Research Group, Newmarket, Ontario Canada; Tristram Bahnson, MD, Duke Clinical Research Institute, Durham, NC; Brian DeVille, MD, The Heart Hospital Baylor Plano, Plano, TX; Kristi Monahan, RN, Mayo Clinic, Rochester, MN.
CABANA Innovative Drug Therapy Committee: John DiMarco, MD (Chair) University of Virginia Health Sciences Center, Charlottesville, VA; Gerald Naccarelli, MD, Penn State Hershey Cardiovascular Institute, Hershey, PA; Peter Kowey, MD, Lankenau Medical Center, Wynnewood, PA; James Reiffel, MD, Columbia University College of Physicians and Surgeons, New York, NY; Mario Gonzalez, MD, Milton Hershey Medical Center, Hershey, PA; Kristi Monahan, RN, Mayo Clinic, Rochester, MN.
ECG Adjudication Committee: Jeanne Poole MD, (Chair), Kris Patton, MD, Jordan Prutkin, MD, University of Washington Medical Center, Seattle, WA; George Johnson, Independent Contractor, Seattle, WA; Nazem Akoum, MD, University of Washington, Seattle, WA; Pierre Auokar, MD, Joseph Blatt, MD, Kaiser Permanente, San Diego, CA; Ulrika (Riki) Birgersdotter-Green, MD, University of California, San Diego, CA; Yong-Mei Cha, MD, Siva Mulpuru, MD, Peter Noseworthy, MD, Mayo Clinic, Rochester, MN; Mina Chung, MD, Cleveland Clinic, Cleveland, OH; Marye Gleva, MD, Washington University Medical Center, St Louis, MO; Taya Glotzer, MD, Hackensack University Medical Center, Hackensack, NJ; Charles Henrikson, MD, Eric Stecker, MD, Oregon Health & Science University, Portland, OR; Yousuf Kanjwal, MD, University of Toledo, Toledo, OH; Jack Kron, MD, Oregon Health & Science University, Portland, OR; Vikas Kuriachan, MD, Alberta Health Services, Alberta Canada; Owen Obel, MD, University of Texas Southwestern, Dallas, TX; Ravi Ranjan, MD, University of Utah, Salt Lake City, UT; Robert Rho, MD, Virginia Mason Medical Center, Seattle WA; Andrea Russo, MD, Cooper University Hospital, Camden, NJ; Renee Sullivan, MD, University of Missouri, Columbia, MO; Wendy Tzou, MD, University of Colorado Health, Denver, CO; Sarina van der Zee, MD, Pacific Heart Institute, Santa Monica, CA; Laura Vitali Serdoz, MD, Klinikum Coburg, Coburg, Germany.
CABANA Rhythm Monitoring: Mauri Wilson, RN, BSN, BSES (Clinical Research Liaison), Wayne Bowen, EMT-P, CCT (Clinical Trial Associate), Medicomp Cardiac Monitoring Centers, Melbourne, FL.
Clinical Site Principal Investigators and Institutions: (Listed in descending order of the number of randomized patients) Evgeny Pokushalov, Alexander Romanov, E. Meshalkin, National Medical Research Center of the Ministry of Health of the Russian Federation, Novosibirsk, Russian Federation (147); T. Jared Bunch, Intermountain Medical Center/Murray, UT (139); Tristram Bahnson, Duke University Medical Center, Durham, NC (133); Georg Noelker, Herz-und Diabeteszentrum NRW, Bad Oeynhausen, Germany (98); Douglas Packer, Mayo Clinic, Rochester, MN (93); Gerhard Hindricks, Herzzentrum Leipzig, Leipzig, Germany (88); Andrey Ardashev, Clinical Hospital # 83 under the Federal Medical and Biological Agency, Moscow, Russia (66); Amiran Revishvili, George Matsonashvili, Bakoulev Scientific Center for Cardiovascular Surgery, Moscow, Russia (52); Pugazhendhi Vijayaraman, Geisinger Wyoming Valley Medical Center, Wilkes-Barre, PA (43); Huseyin Ince, Universitat Rostock, Rostock, Germany (previously Dietmar Baensch) (42); Christopher Piorkowski, Technische Universitat Dresden, Dresden, Germany (41); Thomas Neumann, Kerckhoff Klinik, Bad Nauheim, Germany (40); George Veenhuyzen, University of Calgary, Calgary, AB (39); Anil Gehi, University of North Carolina at Chapel Hill, Chapel Hill, NC (previously Paul Mounsey) (38); David Wilber, Loyola University Medical Center, Maywood, IL (36); Felix Sogade, Georgia Arrhythmia Consultants, Macon, GA (34); Carlo Pappone, Policlinico San Donato Center of Clinical Arrhythmia and Electrophysiology, San Donato Milanese, Italy (previously Riccardo Cappato) (32); Adam Berman, Georgia Regents University, Augusta, GA (31); Alaa Shalaby, V.A. Pittsburgh Healthcare System, Pittsburgh, PA (25); Karl-Heinz Kuck, Asklepios Klinik St George, Hamburg, Germany (25); Blair Halperin, Providence St Vincent Medical Center, Portland, OR (25); Venkat Tholakanahalli, Minneapolis V.A. Medical Center, Minneapolis, MN (24); Eugen Palma, Montefiore Medical Center, New York, NY (24); John Holshouser, The Sanger Clinic, PA, Charlotte, NC (24); Nitish Badhwar, University of California at San Francisco Medical Center, San Francisco, CA (23); Haroon Rashid, Virginia Hospital Center - Arlington, VA (23); Craig Cameron, Oklahoma Heart Institute, Tulsa, OK (22); John Hummel, The Ohio State University Medical Center, Columbus, OH (22); Pablo Saavedra, Vanderbilt University Medical Center, Nashville, TN (previously Dawood Darbar) (21); J. Brian Deville, The Heart Hospital Baylor Plano, Plano, TX (21); Julian Chun, CCB - Cardioaniologisches Centrum Bethanien, Frankfurt, Germany (20); Javier Roman-Gonzalez, South Texas Cardiovascular Consultants, San Antonio, TX (20); Stephen Willems, Universitares Herzzentrum Hamburg, Hamburg, Germany (20); Hasan Garan, Columbia University Medical Center, New York, NY (20); Eric Michael Crespo, Hartford Hospital, Hartford, CT (19); Peter Cheung, Scott and White Memorial Hospital, Temple, TX (previously David Fitzgerald) (18); Gerian Groenefeld, Asklepios Klinik Barmbek, Hamburg, Germany (17); Claudio Schuger, Henry Ford Hospital, Detroit, MI (16); Tariq Salam, Cardiac Study Center, Tacoma, WA (16); Yanzong Yang, The First Affiliated Hospital of Dalian Medical University, Dalian, China (15); Carlo Pappone, Maria Cecilia Hospital, Cotignola, Italy (15); Dan Wichterle, Charles University, Prague 2, Czech Republic (15); Johannes Brachmann, Klinikum Coburg, Coburg, Germany (15); Josef Kautzner, Clinic of Cardiology IKEM Medical Institute, Prague 4, Czech Republic (15); John Jayachandran, Baylor All Saints Medical Center, Ft Worth, TX (15); Young-Hoon Kim, Korea University Anam Hospital, Seoul, Korea (14); Christopher Cole, Penrose St Francis Health Services, Colorado Springs, CO (14); Bengt Herweg, University of South Florida, Tampa, FL (13); Martin Lowe, The Heart Hospital, London, United Kingdom (12); Anne Dougherty, University of Texas Health Science Center at Houston, Houston, TX (previously Bharat Kantharia, Nada Memon) (12); Sergey Popov, Scientific Research Institute of Cardiology of Siberian Dept of Russian Academy of Medical Sciences, Tomsk, Russia (11); Martin Lowe, St Bartholomew's Hospital, London, United Kingdom (previously Richard Schilling) (11); Stefan Spitzer, Praxisklinik Herz and GefaBe, Dresden, Germany (11); Robert Bernstein, Sentara Norfolk General Hospital, Norfolk, VA (11); Jay Simonson, Park Nicollet Heart and Vascular Center/Methodist Hospital, St Louis Park, MN (11); Eric Buch, University of California Los Angeles, Los Angeles, CA (10); Shulin Wu, Guangdong Provincial People's Hospital, Guangzhou, China (10); Mohammed Khan, Alexian Brothers Medical Center, Elk Grove Village, IL (10); Timothy Shinn, St Joseph Mercy Hospital, Ann Arbor, MI (previously James Kappler) (10); Petr Neuzil, Na Homolce Hospital, Prague, Czech Republic (9); James Mangrum, University of Virginia Health System, Charlottesville, VA (9); Hugh Calkins, Johns Hopkins Hospital, Baltimore, MD (9); Mario Gonzalez, Penn State University Cardiovascular Center, Hershey, PA (9); Moussa Mansour, Massachusetts General Hospital, Boston, MA (9); Markus Zabel, Georg-August-University, Goettingen, Germany (8); Jonathan Kalman, Royal Melbourne Hospital, Parkville, Australia (8); Jose Sanchez, St John's Mercy Heart Hospital, St Louis, MO (8); Steven Rothman, Lankenau Medical Center, Wynnewood, PA (8); Anil Bhandari, Good Samaritan Hospital, Los Angeles, CA (8); Cynthia Tracy, George Washington University Medical Center, Washington, DC (8); Raul Mitrani, University of Miami Health System, Miami, FL (7); Vicken Vorperian, Waukesha Memorial Hospital, Waukesha, WI (7); Derek Connelly, Golden Jubilee Hospital, Glasgow, United Kingdom (7); Darryl Wells, Swedish Medical Center - Providence Campus, Seattle, WA (7); Chang-Sheng Ma, Beijing Anzhen Hospital, Beijing, China (7); Atul Verma, Southlake Regional Health Centre, Newmarket, ON (7); S. Luke Kusmirek, Drexel University College of Medicine, Philadelphia, PA (7); Melissa Robinson, University of Washington Medical Center, Seattle, WA (previously Robert Rho, Mohan Viswanathan) (7); Donald Rubenstein, Greenville Hospital System University Medical Center, Greenville, SC (6); Emilio Vanoli, Policlinico Multimedical Cardiology and Arrhythmia Centre, Milan, Italy (previously Annibale Montenero) (6); Shu Zhang, Fuwai Hospital, Beijing, China (6); Jennifer Cummings, The University of Toledo, Toledo, OH (previously Mohammed Kanjwal) (6); Mohan Viswanathan, Stanford University Medical Center, Stanford, CA (previously Amin Al Ahmad, Paul Zei) (6); George Monir, Florida Hospital, Orlando, FL (6); Francis Marchlinski, University of Pennsylvania Health System, Philadelphia, PA (6); Jay Franklin, Baylor Heart and Vascular Hospital, Dallas, TX (previously Robert Kowal) (6); Bruce Koplan, Brigham and Women's Hospital, Boston, MA (previously Gregory Michaud) (6); Prashanthan Sanders, Royal Adelaide Hospital, Adelaide, Australia (5); Eric Rashba, Stony Brook University Medical Center, Stony Brook, NY (5); Mark Gallagher, St George's Hospital Medical School, London, United Kingdom (5); Bernd Gonska, St Vincentius-Kliniken, Karlsruhe, Germany (5); Minglong Chen, First Affiliated Hospital of Nanjing Medical University, Nanjing, China (5); Peter Leong-Sit, University of Western Ontario - London Health Sciences Centre, London, Ontario (5); John Zimmerman, Hackensack University Medical Center, Hackensack, NJ (5); Nayer Pezeshkian, University of California Davis Medical Center, Sacramento, CA (5); Andrew Cohen, The Medical Center of Aurora, Aurora, CO (5); Saulius Kalvaitis, St Louis Heart and Vascular, St Louis, MO (4); David Davies, St Mary's Hospital, London, United Kingdom (4); Martin Borggrefe, University Hospital of Mannheim, Mannheim, Germany (4); Hui-Nam Pak, Yonsei University Severance Hospital, Seoul, Korea (4); Andrea Russo, Cooper University Hospital, Camden, NJ (4); Charles Henrikson, Oregon Health and Science University, Portland, OR (previously Jack Kron) (4); Gerald Greer, Arkansas Cardiology, PA, Little Rock, AR (4); James Coromilas, Robert Wood Johnson University Hospital, New Brunswick, NJ (3); Farhat Khairallah, Tallahassee Memorial Hospital, Tallahassee, FL (3); Guillermo Sosa-Suarez, Albany Associates in Cardiology, Albany, NY (3); Bruce Lindsay, Cleveland Clinic Foundation, Cleveland, OH (3); Westby Fisher, North Shore University Health System, Evanston Hospital, Evanston, IL (3); Steven Bailin, Mercy Medical Center, Des Moines, IA (3); Andy Tran, Scottsdale Healthcare, Scottsdale, AZ (2); Zdenek Starek, St Anne's University Hospital, ICRC, Brno, Czech Republic (2); Mark Preminger, The Valley Hospital, Ridgewood, NJ (2); Robert Sheppard, Northside Hospital and Heart Institute, St Petersburg, FL (2); Alexandru Costea, University of Cincinnati Medical Center, Cincinnati, OH (2); Kenneth Ellenbogen, Virginia Commonwealth University Medical Center, Richmond, VA (2); Thomas Arentz, Herz-Zentrum Bad Krozingen, Bad Krozingen, Germany (1); Roberto De Ponti, Ospedale di Circolo e Fondazione Macchi, Varese, Italy (1); Ryan Aleong, University of Colorado Hospital, Aurora, CO (1); Byron Colley III, Jackson Heart Clinic, Jackson, MS (1); Khawaja Baig, Medisync, Cincinnati, OH (1); Kousik Krishnan, Rush University Medical Center, Chicago, IL (1); Syamkumar Divakara Menon, Hamilton Health Sciences, Hamilton, ON (previously Carlos Morillo) (1); Tony Simmons, Wake Forest University Health Sciences, Winston Salem, NC (1); Gregory Bruce, Memorial Health Care System, Chattanooga, TN (1); Larry Chinitz, Tisch Hospital (New York University Langone Medical Center), New York, NY (1); Andrea Natale, Texas Cardiac Arrhythmia, Austin, TX (1); Riccardo Cappato, IRCCS Istituto Clinico Humanitas, Milano, Italy.
Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung, and Blood Institute, the National Institutes of Health, or the US Department of Health and Human Services.
Meeting Presentation: This study was presented at the Late Breaking Trials session of the European Society of Cardiology Congress; August 26, 2018; Munich, Germany.
Data Sharing Statement: See Supplement 3.
Additional Contributions: We are particularly indebted to the coordinators at the CABANA sites who collected study data and to the patients who agreed to provide their quality of life data for the trial.
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