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January 2021, Vol 4, No. 1

HEALTH INFORMATICS

Assessment of a Clinical Trial–Derived Survival Model in Patients With Metastatic Castration-Resistant Prostate Cancer

This cohort study assesses the performance of a prognostic survival model derived from randomized clinical trial data when the model is applied to real-world data from the electronic health records of patients with metastatic castration-resistant prostate cancer.

open access
JAMA Netw Open. 2021;4(1):e2031730. doi:10.1001/jamanetworkopen.2020.31730
Abstract Full Text pdf link PDF
SURGERY

Temporal Trends in Incidence Rates of Lower Extremity Amputation and Associated Risk Factors Among Patients Using Veterans Health Administration Services From 2008 to 2018

This cohort study examines temporal trends and risk factors associated with lower extremity amputation among veterans using Veterans Health Administration services.

open access
JAMA Netw Open. 2021;4(1):e2033953. doi:10.1001/jamanetworkopen.2020.33953
Abstract Full Text pdf link PDF
GLOBAL HEALTH

Assessment of Knowledge of HIV/AIDS and Association With Socioeconomic Disparities Among Young Women in Low- and Middle-Income Countries, 2003 to 2018

This cross-sectional study provides an up-to-date assessment of the levels of and changes in knowledge of HIV/AIDs and its association with socioeconomic disparity among young women in low- and middle-income countries.

open access
JAMA Netw Open. 2021;4(1):e2035000. doi:10.1001/jamanetworkopen.2020.35000
Abstract Full Text pdf link PDF
RESEARCH LETTER

Trends in Within-Class Changes in US Average Wholesale Prices for Brand-Name Medications for Common Conditions From 2015 to 2020

This cross-sectional study examines within-class changes in US wholesale drug prices for brand-name medications from 2015 to 2020.

open access
JAMA Netw Open. 2021;4(1):e2035064. doi:10.1001/jamanetworkopen.2020.35064
Abstract Full Text pdf link PDF
RESEARCH LETTER STATISTICS AND RESEARCH METHODS

Physician Density by Specialty Type in Urban and Rural Counties in the US, 2010 to 2017

This cross-sectional study uses data from the American Medical Association Physician Masterfile to examine physician density by specialty type across metropolitan and rural US counties from 2010 to 2017.

open access
JAMA Netw Open. 2021;4(1):e2033994. doi:10.1001/jamanetworkopen.2020.33994
Abstract Full Text pdf link PDF
RESEARCH LETTER MEDICAL EDUCATION

Demographic Factors and Academic Outcomes Associated With Taking a Leave of Absence From Medical School

This cross-sectional study uses 2007-2012 data from the Association of American Medical Colleges’ Matriculating Student Questionnaire to evaluate student factors and academic outcomes associated with taking a leave of absence from medical school.

open access
JAMA Netw Open. 2021;4(1):e2033570. doi:10.1001/jamanetworkopen.2020.33570
Abstract Full Text pdf link PDF
CORRECTION

Errors in Citations, Data Reporting, and the Supplement

open access
JAMA Netw Open. 2021;4(1):e2037105. doi:10.1001/jamanetworkopen.2020.37105
Abstract Full Text pdf link PDF
HEALTH INFORMATICS

Evaluation of Attention Switching and Duration of Electronic Inbox Work Among Primary Care Physicians

This cross-sectional study examines primary care physicians’ frequency of attention switching associated with electronic inbox work and identifies potentially modifiable factors associated with attention switching and inbox work duration.

open access
JAMA Netw Open. 2021;4(1):e2031856. doi:10.1001/jamanetworkopen.2020.31856
Abstract Full Text pdf link PDF
HEALTH POLICY

Comparison of Access to Primary Care Medical and Dental Appointments Between Simulated Patients Who Were Deaf and Patients Who Could Hear

This cross-sectional study compares the rate at which patients who are deaf are offered primary care medical or dental appointments with the rate at which appointments are offered to patients who can hear.

open access
JAMA Netw Open. 2021;4(1):e2032207. doi:10.1001/jamanetworkopen.2020.32207
Abstract Full Text pdf link PDF
HEALTH POLICY

Assessment of the Patient Protection and Affordable Care Act’s Increase in Fees for Primary Care and Access to Care for Dual-Eligible Beneficiaries

This cohort study evaluates whether the Affordable Care Act’s increase in Medicaid fees to Medicare levels for primary care practitioners was associated with increases in primary care visits for dual-eligible Medicare and Medicaid beneficiaries.

open access
JAMA Netw Open. 2021;4(1):e2033424. doi:10.1001/jamanetworkopen.2020.33424
Abstract Full Text pdf link PDF
PULMONARY MEDICINE

Association of Obstructive Sleep Apnea With the Risk of Male Infertility in Taiwan

This case-control study examines the demographic variables, comorbidities, exposure to obstructive sleep apnea, and obstructive sleep apnea therapies in adult men with or without an infertility diagnosis.

open access
JAMA Netw Open. 2021;4(1):e2031846. doi:10.1001/jamanetworkopen.2020.31846
Abstract Full Text pdf link PDF
ONCOLOGY

Evaluation of Clear Cell, Papillary, and Chromophobe Renal Cell Carcinoma Metastasis Sites and Association With Survival

This cohort study evaluates the prevalence of metastasis sites for clear cell, papillary, and chromophobe renal cell carcinoma (RCC) and examines the association between site of metastasis and overall survival.

open access
JAMA Netw Open. 2021;4(1):e2021869. doi:10.1001/jamanetworkopen.2020.21869
Abstract Full Text pdf link PDF
HEALTH POLICY

Reports of Forgone Medical Care Among US Adults During the Initial Phase of the COVID-19 Pandemic

This survey study examines the frequency of and reasons for reported forgone care among US adults during the COVID-19 pandemic.

open access
JAMA Netw Open. 2021;4(1):e2034882. doi:10.1001/jamanetworkopen.2020.34882
Abstract Full Text pdf link PDF
RESEARCH LETTER PUBLIC HEALTH

Suicide-Related Internet Searches During the Early Stages of the COVID-19 Pandemic in the US

This cross-sectional study assesses trends in suicide-related internet search rates in the early stages of the COVID-19 pandemic in the US.

open access
JAMA Netw Open. 2021;4(1):e2034261. doi:10.1001/jamanetworkopen.2020.34261
Abstract Full Text pdf link PDF
RESEARCH LETTER PUBLIC HEALTH

Suicide Deaths During the COVID-19 Stay-at-Home Advisory in Massachusetts, March to May 2020

This cohort study evaluates the association between the coronavirus disease 2019 (COVID-19) stay-at-home orders and suicide deaths in Massachusetts.

open access
JAMA Netw Open. 2021;4(1):e2034273. doi:10.1001/jamanetworkopen.2020.34273
Abstract Full Text pdf link PDF
RESEARCH LETTER SUBSTANCE USE AND ADDICTION

Racial/Ethnic Disparities in Unintentional Fatal and Nonfatal Emergency Medical Services–Attended Opioid Overdoses During the COVID-19 Pandemic in Philadelphia

This cross-sectional study describes the differential associations of the coronavirus disease 2019 (COVID-19) pandemic with opioid-related overdoses among racial/ethnic groups in Philadelphia, Pennsylvania.

open access
JAMA Netw Open. 2021;4(1):e2034878. doi:10.1001/jamanetworkopen.2020.34878
Abstract Full Text pdf link PDF
HEALTH POLICY

Associations of Government-Mandated Closures and Restrictions With Aggregate Mobility Trends and SARS-CoV-2 Infections in Nigeria

This cross-sectional study uses data from smartphone users to examine the association of government-mandated closures and restrictions with aggregate mobility and the association of changes in mobility with confirmed SARS-CoV-2 infections in Nigeria.

open access
JAMA Netw Open. 2021;4(1):e2032101. doi:10.1001/jamanetworkopen.2020.32101
Abstract Full Text pdf link PDF
PUBLIC HEALTH

Comparison of All-Cause Mortality Rates and Inequities Between Black and White Populations Across the 30 Most Populous US Cities

This cross-sectional study examines city-level data from the 30 most populous US cities regarding all-cause mortality rates and racial inequities within cities and seeks to determine whether these measures changed during the past decade.

open access
JAMA Netw Open. 2021;4(1):e2032086. doi:10.1001/jamanetworkopen.2020.32086
Abstract Full Text pdf link PDF
HEALTH POLICY

Association of Social and Economic Inequality With Coronavirus Disease 2019 Incidence and Mortality Across US Counties

This cross-sectional ecological analysis quantifies the association of economic inequality, racial/ethnic composition, political factors, and state health care policy with the incidence and mortality burden associated with coronavirus disease 2019 (COVID-19) at the US county level.

open access
JAMA Netw Open. 2021;4(1):e2034578. doi:10.1001/jamanetworkopen.2020.34578
Abstract Full Text pdf link PDF
NUTRITION, OBESITY, AND EXERCISE

Evaluation of Nutritional Support and In-Hospital Mortality in Patients With Malnutrition

This cohort study examines the association of nutritional support with mortality rates among hospitalized patients with malnutrition in Switzerland.

open access
JAMA Netw Open. 2021;4(1):e2033433. doi:10.1001/jamanetworkopen.2020.33433
Abstract Full Text pdf link PDF
NEPHROLOGY

Development and Validation of a Deep Learning Model to Quantify Glomerulosclerosis in Kidney Biopsy Specimens

This prognostic study compares performances between pathologists and a deep learning model to quantify percent global glomerulosclerosis on images of kidney biopsy specimens and assesses the potential benefit of the model on donor kidney discard rates.

open access
JAMA Netw Open. 2021;4(1):e2030939. doi:10.1001/jamanetworkopen.2020.30939
Abstract Full Text pdf link PDF
OBSTETRICS AND GYNECOLOGY

Perceptions and Motivations for Uterus Transplant in Transgender Women

This survey study assesses perceptions of and motivations for uterus transplant among transgender women and explores their willingness to undergo the procedure.

open access
JAMA Netw Open. 2021;4(1):e2034561. doi:10.1001/jamanetworkopen.2020.34561
Abstract Full Text pdf link PDF
RESEARCH LETTER INFECTIOUS DISEASES

Factors Associated With US Public Motivation to Use and Distribute COVID-19 Self-tests

This survey study examines factors associated with motivation to use and distribute self-tests for COVID-19 infection among US adults.

open access
JAMA Netw Open. 2021;4(1):e2034001. doi:10.1001/jamanetworkopen.2020.34001
Abstract Full Text pdf link PDF
PUBLIC HEALTH

Association of Intensive Care Unit Patient Load and Demand With Mortality Rates in US Department of Veterans Affairs Hospitals During the COVID-19 Pandemic

This cohort study examines the association of patient caseload and demand with mortality among patients with coronavirus disease 2019 (COVID-19) in US Veterans Affairs (VA) intensive care units.

open access has audio
JAMA Netw Open. 2021;4(1):e2034266. doi:10.1001/jamanetworkopen.2020.34266
Abstract Full Text pdf link PDF
SUBSTANCE USE AND ADDICTION

Assessment of Racial Differences in Pharmacotherapy Efficacy for Smoking Cessation: Secondary Analysis of the EAGLES Randomized Clinical Trial

This secondary analysis of the Evaluating Adverse Events in a Global Smoking Cessation Study (EAGLES) randomized clinical trial compares the pharmacotherapy efficacy of varenicline, bupropion, and nicotine replacement therapy in quitting smoking for Black vs White US smokers.

open access
JAMA Netw Open. 2021;4(1):e2032053. doi:10.1001/jamanetworkopen.2020.32053
Abstract Full Text pdf link PDF
STATISTICS AND RESEARCH METHODS

Cost-effectiveness of Pembrolizumab as a Second-Line Therapy for Hepatocellular Carcinoma

This economic evaluation analyzes the cost-effectiveness of pembrolizumab as a second-line treatment in patients with advanced hepatocellular carcinoma.

open access
JAMA Netw Open. 2021;4(1):e2033761. doi:10.1001/jamanetworkopen.2020.33761
Abstract Full Text pdf link PDF
MEDICAL EDUCATION

Measurement of American Indian and Alaska Native Racial Identity Among Medical School Applicants, Matriculants, and Graduates, 1996-2017

This cohort study uses interrupted time series regression to assess the association between changes in race/ethnicity data collection in the American Medical College Application System survey and trends in applicants, matriculants, and graduates self-reporting as American Indian and Alaska Native.

open access
JAMA Netw Open. 2021;4(1):e2032550. doi:10.1001/jamanetworkopen.2020.32550
Abstract Full Text pdf link PDF
CARDIOLOGY

Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study

This mendelian randomization study evaluates summary statistics from genome-wide associations involving more than 1 million individuals to assess whether there are differential associations between genetic liability to smoking and risk of coronary artery disease, peripheral artery disease, and large-artery stroke.

open access
JAMA Netw Open. 2021;4(1):e2034461. doi:10.1001/jamanetworkopen.2020.34461
Abstract Full Text pdf link PDF
RESEARCH LETTER PUBLIC HEALTH

Epidemiology of Coronavirus Disease 2019 in US Immigration and Customs Enforcement Detention Facilities

This cohort study describes the burden of coronavirus disease 2019 among people detained by US Immigration and Customs Enforcement compared with the US population.

open access
JAMA Netw Open. 2021;4(1):e2034409. doi:10.1001/jamanetworkopen.2020.34409
Abstract Full Text pdf link PDF
ONCOLOGY

Accuracy of Magnetic Resonance Imaging–Guided Biopsy to Verify Breast Cancer Pathologic Complete Response After Neoadjuvant Chemotherapy: A Nonrandomized Controlled Trial

This nonrandomized controlled trial uses data from a single tertiary care center in the US to investigate the accuracy of magnetic resonance imaging (MRI)–guided biopsy compared with surgical resection for assessing pathologic complete response after neoadjuvant chemotherapy in patients with breast cancer.

open access
JAMA Netw Open. 2021;4(1):e2034045. doi:10.1001/jamanetworkopen.2020.34045
Abstract Full Text pdf link PDF
ONCOLOGY

Evaluation of Aspirin Use With Cancer Incidence and Survival Among Older Adults in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

This cohort study investigates the association of aspirin use with risk of developing new cancers and site-specific cancer-associated survival in bladder, breast, esophageal, gastric, pancreatic, and uterine cancers.

open access
JAMA Netw Open. 2021;4(1):e2032072. doi:10.1001/jamanetworkopen.2020.32072
Abstract Full Text pdf link PDF
NEUROLOGY

Association of Cognitive Function Trajectories in Centenarians With Postmortem Neuropathology, Physical Health, and Other Risk Factors for Cognitive Decline

This cohort study examines trajectories of cognitive function and their associations with cognitive reserve, physical health, and postmortem levels of neuropathology associated with Alzheimer disease in Dutch centenarians.

open access
JAMA Netw Open. 2021;4(1):e2031654. doi:10.1001/jamanetworkopen.2020.31654
Abstract Full Text pdf link PDF
GERIATRICS

A Method to Quantify Mean Hypertension Treatment Daily Dose Intensity Using Health Care System Data

This cross-sectional study develops and validates a method to more precisely quantify dose intensity of hypertension treatment using only health system administrative pharmacy fill data.

open access
JAMA Netw Open. 2021;4(1):e2034059. doi:10.1001/jamanetworkopen.2020.34059
Abstract Full Text pdf link PDF
NEPHROLOGY

Facility-Level Variation in Dialysis Use and Mortality Among Older Veterans With Incident Kidney Failure

This cohort study examines which patient and facility factors in the US Department of Veterans Affairs health care system are associated with dialysis approaches and outcomes.

open access
JAMA Netw Open. 2021;4(1):e2034084. doi:10.1001/jamanetworkopen.2020.34084
Abstract Full Text pdf link PDF
INFECTIOUS DISEASES

Association of Immunosuppression and Viral Load With Subcortical Brain Volume in an International Sample of People Living With HIV

This cross-sectional study examines structural brain associations with CD4+ T-cell count and viral load in HIV-positive individuals taking and not taking combination antiretroviral therapy.

open access
JAMA Netw Open. 2021;4(1):e2031190. doi:10.1001/jamanetworkopen.2020.31190
Abstract Full Text pdf link PDF
RESEARCH LETTER MEDICAL EDUCATION

Assessment of Interruptive Behavior at Residency Teaching Conferences by Gender

This cohort study examines interruptions by residents and faculty discussants during residency teaching conferences by gender.

open access
JAMA Netw Open. 2021;4(1):e2033469. doi:10.1001/jamanetworkopen.2020.33469
Abstract Full Text pdf link PDF
CORRECTION

Error in Results Section

open access
JAMA Netw Open. 2021;4(1):e2036665. doi:10.1001/jamanetworkopen.2020.36665
Abstract Full Text pdf link PDF
EDITORIAL

Reporting Clinical Studies Affected by the COVID-19 Pandemic: Guidelines for Authors

open access
JAMA Netw Open. 2021;4(1):e2036155. doi:10.1001/jamanetworkopen.2020.36155
Abstract Full Text pdf link PDF
INFECTIOUS DISEASES

Safety, Reactogenicity, and Health-Related Quality of Life After Trivalent Adjuvanted vs Trivalent High-Dose Inactivated Influenza Vaccines in Older Adults: A Randomized Clinical Trial

This randomized clinical trial assesses whether injection-site pain and reactogenicity are noninferior in trivalent adjuvanted inactivated influenza vaccine (aIIV3) compared with trivalent high-dose inactivated influenza vaccine (HD-IIV3) among adults aged 65 years and older.

open access
JAMA Netw Open. 2021;4(1):e2031266. doi:10.1001/jamanetworkopen.2020.31266
Abstract Full Text pdf link PDF
NEPHROLOGY

Association of the Estimated Glomerular Filtration Rate With vs Without a Coefficient for Race With Time to Eligibility for Kidney Transplant

This cohort study assesses the association between estimated glomerular filtration rate (eGFR) calculated with vs without a coefficient for race and time to achievement of an eGFR less than 20 mL/min/1.73 m2.

open access
JAMA Netw Open. 2021;4(1):e2034004. doi:10.1001/jamanetworkopen.2020.34004
Abstract Full Text pdf link PDF
GERIATRICS

Information Sharing Practices Between US Hospitals and Skilled Nursing Facilities to Support Care Transitions

This survey study evaluates the current state of the completeness, timeliness, and usability of information sharing, and identifies characteristics associated with better sharing, to support patient care transitions between hospitals and skilled nursing facilities.

open access
JAMA Netw Open. 2021;4(1):e2033980. doi:10.1001/jamanetworkopen.2020.33980
Abstract Full Text pdf link PDF
ONCOLOGY

Medical Oncology Professionals’ Perceptions of Telehealth Video Visits

This qualitative study surveyed physicians and other health professionals working in oncology to determine the perceived advantages and disadvantages of telehealth video visits in cancer care.

open access
JAMA Netw Open. 2021;4(1):e2033967. doi:10.1001/jamanetworkopen.2020.33967
Abstract Full Text pdf link PDF
RESEARCH LETTER CARDIOLOGY

Referral Rates for Cardiac Rehabilitation Among Eligible Inpatients After Implementation of a Default Opt-Out Decision Pathway in the Electronic Medical Record

This quality improvement study assesses referral rates for cardiac rehabilitation after a default opt-out option is added to the decision pathway in the electronic medical record.

open access
JAMA Netw Open. 2021;4(1):e2033472. doi:10.1001/jamanetworkopen.2020.33472
Abstract Full Text pdf link PDF
CORRECTION

Error in References Section

open access
JAMA Netw Open. 2021;4(1):e2036103. doi:10.1001/jamanetworkopen.2020.36103
Abstract Full Text pdf link PDF
NUTRITION, OBESITY, AND EXERCISE

Effect of Bimagrumab vs Placebo on Body Fat Mass Among Adults With Type 2 Diabetes and Obesity: A Phase 2 Randomized Clinical Trial

This randomized clinical trial evaluates the efficacy and safety of bimagrumab on body composition and glycemic control in adults with type 2 diabetes and overweight or obesity.

open access
JAMA Netw Open. 2021;4(1):e2033457. doi:10.1001/jamanetworkopen.2020.33457
Abstract Full Text pdf link PDF
PUBLIC HEALTH

Longitudinal Associations of Mental Disorders With Physical Diseases and Mortality Among 2.3 Million New Zealand Citizens

This cohort study uses data from the New Zealand Integrated Data Infrastructure database to examine the association of mental disorders with subsequent physical diseases and mortality among the New Zealand population over a 30-year observation period.

open access
JAMA Netw Open. 2021;4(1):e2033448. doi:10.1001/jamanetworkopen.2020.33448
Abstract Full Text pdf link PDF
DIABETES AND ENDOCRINOLOGY

Evaluation of Patient Willingness to Adopt Remote Digital Monitoring for Diabetes Management

This survey study identifies the minimum effectiveness patients with type 1 and type 2 diabetes report they require to adopt 36 different remote digital diabetes monitoring scenarios.

open access
JAMA Netw Open. 2021;4(1):e2033115. doi:10.1001/jamanetworkopen.2020.33115
Abstract Full Text pdf link PDF
ONCOLOGY

Cost-effectiveness of Prostate Radiation Therapy for Men With Newly Diagnosed Low-Burden Metastatic Prostate Cancer

This economic evaluation assesses the cost-effectiveness of the addition of prostate radiation therapy to androgen deprivation therapy for men with low-volume metastatic hormone-sensitive prostate cancer.

open access
JAMA Netw Open. 2021;4(1):e2033787. doi:10.1001/jamanetworkopen.2020.33787
Abstract Full Text pdf link PDF
RESEARCH LETTER ANESTHESIOLOGY

Association of Automated Text Messaging With Patient Response Rate After Same-Day Surgery

This quality improvement study assesses the association of automated text messaging follow-up with the patient response rate after same-day surgery.

open access
JAMA Netw Open. 2021;4(1):e2033312. doi:10.1001/jamanetworkopen.2020.33312
Abstract Full Text pdf link PDF
RESEARCH LETTER ONCOLOGY

Association of Pertuzumab, Trastuzumab, and Docetaxel Combination Therapy With Overall Survival in Patients With Metastatic Breast Cancer

This cohort study compares the findings of combined pertuzumab, trastuzumab, and docetaxel therapy in women with metastatic breast cancer with those in the CLEOPATRA trial.

open access
JAMA Netw Open. 2021;4(1):e2027764. doi:10.1001/jamanetworkopen.2020.27764
Abstract Full Text pdf link PDF
PUBLIC HEALTH

Effect of Exposure to e-Cigarettes With Salt vs Free-Base Nicotine on the Appeal and Sensory Experience of Vaping: A Randomized Clinical Trial

This randomized clinical trial assessed whether controlled exposure to e-cigarette puffs with salt vs free-base nicotine formulations improved the appeal and sensory experience of vaping among adult current nicotine or tobacco product users.

open access
JAMA Netw Open. 2021;4(1):e2032757. doi:10.1001/jamanetworkopen.2020.32757
Abstract Full Text pdf link PDF
ONCOLOGY

Association of Race, Socioeconomic Factors, and Treatment Characteristics With Overall Survival in Patients With Limited-Stage Small Cell Lung Cancer

This cohort study investigates the associations of race, socioeconomic factors, and treatment characteristics with overall survival (OS) among patients with limited-stage small cell lung cancer (SCLC).

open access
JAMA Netw Open. 2021;4(1):e2032276. doi:10.1001/jamanetworkopen.2020.32276
Abstract Full Text pdf link PDF
PEDIATRICS

Parental Factors Associated With the Decision to Participate in a Neonatal Clinical Trial

This survey study compared parents who chose to participate in a neonatal clinical trial with those who declined, assessing differences in demographic characteristics, opinions on the severity of their child’s medical condition, and levels of trust in medical researchers.

open access
JAMA Netw Open. 2021;4(1):e2032106. doi:10.1001/jamanetworkopen.2020.32106
Abstract Full Text pdf link PDF
PUBLIC HEALTH

Evaluation of Revised US Preventive Services Task Force Lung Cancer Screening Guideline Among Women and Racial/Ethnic Minority Populations

This cross-sectional study assesses the changes associated with the revised US Preventive Services Task Force guideline with lung cancer screening eligibility among female, Black, and Hispanic populations using a large nationwide survey.

open access
JAMA Netw Open. 2021;4(1):e2033769. doi:10.1001/jamanetworkopen.2020.33769
Abstract Full Text pdf link PDF
PSYCHIATRY

Assessment of Suicidal Behaviors Among Individuals With Autism Spectrum Disorder in Denmark

This cohort study uses national register data to analyze whether people with ASD have higher rates of suicide attempt and suicide compared with people without ASD, identify potential risk factors for suicide attempts and suicide among those with ASD, and examine associations with comorbid disorders.

open access
JAMA Netw Open. 2021;4(1):e2033565. doi:10.1001/jamanetworkopen.2020.33565
Abstract Full Text pdf link PDF
ONCOLOGY

Evaluation of the Cost-effectiveness of Doublet Therapy in Metastatic BRAF Variant Colorectal Cancer

This economic evaluation uses Markov modeling to identify and compare the cost and utility of doublet and standard treatments for patients with BRAF V600E variant colorectal cancer.

open access
JAMA Netw Open. 2021;4(1):e2033441. doi:10.1001/jamanetworkopen.2020.33441
Abstract Full Text pdf link PDF
RESEARCH LETTER MEDICAL EDUCATION

Assessment of Skin Phenotype Representation in a Popular Medical Licensing Educational Resource

This cross-sectional study examines the representation of darker skin phenotypes in tools used by students in preparation for medical licensure testing.

open access
JAMA Netw Open. 2021;4(1):e2033164. doi:10.1001/jamanetworkopen.2020.33164
Abstract Full Text pdf link PDF
SURGERY

Outcomes After Elective Inguinal Hernia Repair Performed by Associate Clinicians vs Medical Doctors in Sierra Leone: A Randomized Clinical Trial

This randomized clinical trial examined outcomes of inguinal hernia surgery performed by associate clinicians vs nonspecialist medical doctors among men in Sierra Leone.

open access
JAMA Netw Open. 2021;4(1):e2032681. doi:10.1001/jamanetworkopen.2020.32681
Abstract Full Text pdf link PDF
CARDIOLOGY

Association of Timing of Electrocardiogram Acquisition After Return of Spontaneous Circulation With Coronary Angiography Findings in Patients With Out-of-Hospital Cardiac Arrest

This cohort study evaluates the association between the time from the return of spontaneous circulation to electrocardiogram (ECG) acquisition and the diagnostic accuracy of ECG for ST-segment elevation myocardial infarction in patients who experience out-of-hospital cardiac arrest.

open access
JAMA Netw Open. 2021;4(1):e2032875. doi:10.1001/jamanetworkopen.2020.32875
Abstract Full Text pdf link PDF
EMERGENCY MEDICINE

Association of Helicopter vs Ground Emergency Medical Transportation With 1-Year Mortality in Denmark

This cohort study assesses whether emergency medical transportation by helicopter vs by ground is associated with differences in mortality among patients in Denmark.

open access
JAMA Netw Open. 2021;4(1):e2033318. doi:10.1001/jamanetworkopen.2020.33318
Abstract Full Text pdf link PDF
MEDICAL EDUCATION

Evaluation of Women and Underrepresented Racial and Ethnic Group Representation in a General Cardiology Fellowship After a Systematic Recruitment Initiative

This quality improvement study assess a systematic recruitment initiative aimed at ensuring adequate matriculation of women and underrepresented racial and ethnic groups in a general cardiology fellowship.

open access
JAMA Netw Open. 2021;4(1):e2030832. doi:10.1001/jamanetworkopen.2020.30832
Abstract Full Text pdf link PDF
RESEARCH LETTER PUBLIC HEALTH

Evaluation of Internet-Based Crowdsourced Fundraising to Cover Health Care Costs in the United States

This serial cross-sectional study examines online crowdsourced fundraising for US health care costs from 2010 to 2018 and evaluates whether there are trends by medical condition and geographic distribution.

open access
JAMA Netw Open. 2021;4(1):e2033157. doi:10.1001/jamanetworkopen.2020.33157
Abstract Full Text pdf link PDF
CORRECTION

Errors in Figure 2

open access
JAMA Netw Open. 2021;4(1):e2034976. doi:10.1001/jamanetworkopen.2020.34976
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HEALTH POLICY

Assessment of Mortality Among Durable Left Ventricular Assist Device Recipients Ineligible for Clinical Trials

This cohort study estimates the proportion of recipients of durable left ventricular assist devices (LVADs) who are ineligible for clinical trial participation and assesses whether an association exists between ineligibility and mortality.

open access
JAMA Netw Open. 2021;4(1):e2032865. doi:10.1001/jamanetworkopen.2020.32865
Abstract Full Text pdf link PDF
PEDIATRICS

Mortality Among Young Adults Born Preterm and Early Term in 4 Nordic Nations

This cohort study examines the risk of all-cause and noncommunicable disease deaths among young adults born preterm and early term in 4 Nordic countries.

open access
JAMA Netw Open. 2021;4(1):e2032779. doi:10.1001/jamanetworkopen.2020.32779
Abstract Full Text pdf link PDF
NEUROLOGY

Assessment of Advanced Glycation End Products and Receptors and the Risk of Dementia

This cohort study examines the association of advanced glycation end products and their receptor with dementia in the general Dutch population.

open access
JAMA Netw Open. 2021;4(1):e2033012. doi:10.1001/jamanetworkopen.2020.33012
Abstract Full Text pdf link PDF
ONCOLOGY

Association of Radiotherapy for Rectal Cancer and Second Gynecological Malignant Neoplasms

This cohort study assesses the association between radiotherapy and the risk of individual types of second gynecological malignant neoplasms in patients with rectal cancer and estimates survival outcomes for patients with secondary cancers.

open access
JAMA Netw Open. 2021;4(1):e2031661. doi:10.1001/jamanetworkopen.2020.31661
Abstract Full Text pdf link PDF
DIABETES AND ENDOCRINOLOGY

Development and Validation of a Machine Learning Model to Predict Near-Term Risk of Iatrogenic Hypoglycemia in Hospitalized Patients

This cohort study of hospitalized patients uses a machine learning model to predict the risk of iatrogenic hypoglycemia within 24 hours after blood glucose measurement during hospitalization.

open access
JAMA Netw Open. 2021;4(1):e2030913. doi:10.1001/jamanetworkopen.2020.30913
Abstract Full Text pdf link PDF
RESEARCH LETTER HEALTH POLICY

Using Lorenz Curves to Measure Racial Inequities in COVID-19 Testing

This cross-sectional study uses Lorenz curves as a metric for quantifying racial inequities in coronavirus disease 2019 (COVID-19) testing.

open access has active quiz
JAMA Netw Open. 2021;4(1):e2032696. doi:10.1001/jamanetworkopen.2020.32696
Abstract Full Text pdf link PDF CME & MOC
CORRECTION

Computational Errors and Incorrect Analysis in Study on Primary School Closures

open access
JAMA Netw Open. 2021;4(1):e2037247. doi:10.1001/jamanetworkopen.2020.37247
Abstract Full Text pdf link PDF
INFECTIOUS DISEASES

SARS-CoV-2 Transmission From People Without COVID-19 Symptoms

This decision analytical model assesses the proportion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmissions in the community that likely occur from persons without symptoms.

open access has active quiz has audio
JAMA Netw Open. 2021;4(1):e2035057. doi:10.1001/jamanetworkopen.2020.35057
Abstract Full Text pdf link PDF CME & MOC
PEDIATRICS

Association of Youth Age at Exposure to Household Dysfunction With Outcomes in Early Adulthood

This cohort study examines the association between age at exposure to household dysfunction during childhood and adolescence and outcomes in early adulthood.

open access
JAMA Netw Open. 2021;4(1):e2032769. doi:10.1001/jamanetworkopen.2020.32769
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SUBSTANCE USE AND ADDICTION

Assessment of Prescription Opioid Medical Use and Misuse Among Parents and Their Adolescent Offspring in the US

This cross-sectional study examines the associations between parental and adolescent prescription opioid medical use and misuse among parent and adolescent dyads in the National Survey on Drug Use and Health.

open access
JAMA Netw Open. 2021;4(1):e2031073. doi:10.1001/jamanetworkopen.2020.31073
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GASTROENTEROLOGY AND HEPATOLOGY

Association of Intensive Endoscopic Screening Burden With Gastric Cancer Detection

This cohort study compares the numbers of endoscopic examinations for gastric cancer screening over quarters of a calendar year with rates of gastric cancer diagnosed during those periods.

open access
JAMA Netw Open. 2021;4(1):e2032542. doi:10.1001/jamanetworkopen.2020.32542
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RESEARCH LETTER PEDIATRICS

Assessment of Duplicate Evidence in Systematic Reviews of Imaging Findings of Children With COVID-19

This cross-sectional study maps a coronavirus research question to illustrate the overlap and shortcomings of the evidence syntheses in this area.

open access has active quiz
JAMA Netw Open. 2021;4(1):e2032690. doi:10.1001/jamanetworkopen.2020.32690
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CORRECTION

Clarification of Role of Funder Statement

open access
JAMA Netw Open. 2021;4(1):e2035088. doi:10.1001/jamanetworkopen.2020.35088
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EMERGENCY MEDICINE

Effect of Machine Learning on Dispatcher Recognition of Out-of-Hospital Cardiac Arrest During Calls to Emergency Medical Services: A Randomized Clinical Trial

This randomized clinical trial examines how a machine learning model trained to identify out-of-hospital cardiac arrest and alert dispatchers during emergency calls affected the recognition of and response to out-of-hospital cardiac arrests.

open access
JAMA Netw Open. 2021;4(1):e2032320. doi:10.1001/jamanetworkopen.2020.32320
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HEALTH POLICY

Proportion, Type, and Characteristics of Physician Entrepreneurship in Massachusetts

This cross-sectional study uses Massachusetts medical licensure and business registration records to examine the proportion of physician-founded companies and the types of businesses started.

open access
JAMA Netw Open. 2021;4(1):e2026938. doi:10.1001/jamanetworkopen.2020.26938
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NEUROLOGY

Progression of Behavioral Disturbances and Neuropsychiatric Symptoms in Patients With Genetic Frontotemporal Dementia

This cohort study uses data from tertiary frontotemporal dementia research clinics across Europe and Canada to assess the frequency and severity of behavioral symptoms and their progression in different forms of genetic frontotemporal dementia.

open access
JAMA Netw Open. 2021;4(1):e2030194. doi:10.1001/jamanetworkopen.2020.30194
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OBSTETRICS AND GYNECOLOGY

Association of Female Reproductive Factors With Incidence of Fracture Among Postmenopausal Women in Korea

This cohort study uses data from the Korean National Health Insurance System database to investigate whether female reproductive factors are associated with fractures among postmenopausal women in Korea.

open access
JAMA Netw Open. 2021;4(1):e2030405. doi:10.1001/jamanetworkopen.2020.30405
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CARDIOLOGY

Evaluation of Dietary Niacin and New-Onset Hypertension Among Chinese Adults

This cohort study of a large nationwide database of Chinese adults assesses the association between dietary niacin intake and the risk of new-onset hypertension.

open access
JAMA Netw Open. 2021;4(1):e2031669. doi:10.1001/jamanetworkopen.2020.31669
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SURGERY

Exploration of Individual and System-Level Well-being Initiatives at an Academic Surgical Residency Program: A Mixed-Methods Study

This mixed-methods study explores individual and workplace factors that are associated with surgical trainees’ well-being, differences by gender identity, and end-user perceptions of experience.

open access
JAMA Netw Open. 2021;4(1):e2032676. doi:10.1001/jamanetworkopen.2020.32676
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RESEARCH LETTER EMERGENCY MEDICINE

Comparison of Out-of-Hospital Cardiac Arrests and Fatalities in the Metro Detroit Area During the COVID-19 Pandemic With Previous-Year Events

This cross-sectional study compares trends in out-of-hospital cardiac arrests and fatalities in the Detroit area during the COVID-19 pandemic with year-earlier events for the same period.

open access has active quiz
JAMA Netw Open. 2021;4(1):e2032331. doi:10.1001/jamanetworkopen.2020.32331
Abstract Full Text pdf link PDF CME & MOC
RESEARCH LETTER PUBLIC HEALTH

Exposure to Common Geographic COVID-19 Prevalence Maps and Public Knowledge, Risk Perceptions, and Behavioral Intentions

This survey study examines knowledge, risk perceptions, and behavioral intentions among survey respondents exposed to different types of COVID-19 prevalence maps.

open access has active quiz
JAMA Netw Open. 2021;4(1):e2033538. doi:10.1001/jamanetworkopen.2020.33538
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IMAGING

Brain Responses to Noxious Stimuli in Patients With Chronic Pain: A Systematic Review and Meta-analysis

This meta-analysis assesses differential brain responses to noxious stimuli in patients with chronic pain using functional magnetic resonance imaging while adhering to current best practices for neuroimaging meta-analyses.

open access
JAMA Netw Open. 2021;4(1):e2032236. doi:10.1001/jamanetworkopen.2020.32236
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HEALTH POLICY

Comparison of Utilization, Costs, and Quality of Medicaid vs Subsidized Private Health Insurance for Low-Income Adults

This cross-sectional study uses data from 3 state agencies merging comprehensive insurance claims with income eligibility data for Colorado Medicaid expansion and Marketplace enrollees to investigate health care utilization, cost, and quality between public and private health insurance for low-income adults.

open access
JAMA Netw Open. 2021;4(1):e2032669. doi:10.1001/jamanetworkopen.2020.32669
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INFECTIOUS DISEASES

Estimation of US SARS-CoV-2 Infections, Symptomatic Infections, Hospitalizations, and Deaths Using Seroprevalence Surveys

This cross-sectional study assesses the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease burden in the US, using surveillance data and seroprevalence surveys to estimate the number of SARS-CoV-2 infections, symptomatic infections, hospitalizations, and deaths through November 15, 2020.

open access has active quiz
JAMA Netw Open. 2021;4(1):e2033706. doi:10.1001/jamanetworkopen.2020.33706
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OPHTHALMOLOGY

Characterization of Ebola Virus–Associated Eye Disease

This cross-sectional analysis of compares rates of ocular sequelae in antibody-positive survivors of Ebola virus disease and antibody-negative close contacts.

open access
JAMA Netw Open. 2021;4(1):e2032216. doi:10.1001/jamanetworkopen.2020.32216
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IMAGING

Noninvasive Prediction of Occult Peritoneal Metastasis in Gastric Cancer Using Deep Learning

This cohort study assesses the use of a deep learning model for predicting occult peritoneal metastasis based on preoperative computed tomographic images in patients with gastric cancer.

open access
JAMA Netw Open. 2021;4(1):e2032269. doi:10.1001/jamanetworkopen.2020.32269
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CARDIOLOGY

Association of Sickle Cell Trait With Incidence of Coronary Heart Disease Among African American Individuals

This cohort study evaluates whether African American individuals with sickle cell trait have a higher incidence of myocardial infarction or composite coronary heart disease outcomes compared with those without sickle cell trait.

open access
JAMA Netw Open. 2021;4(1):e2030435. doi:10.1001/jamanetworkopen.2020.30435
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ENVIRONMENTAL HEALTH

Associations Between Simulated Future Changes in Climate, Air Quality, and Human Health

This modeling study uses 2 climate models and under 2 air pollutant emission scenarios to model the associations between future changes in climate, air quality, and human health.

open access
JAMA Netw Open. 2021;4(1):e2032064. doi:10.1001/jamanetworkopen.2020.32064
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SURGERY

Derivation of Patient-Defined Adverse Cardiovascular and Noncardiovascular Events Through a Modified Delphi Process

This qualitative study attempts to derive patient-defined adverse cardiovascular and noncardiovascular events through a modified Delphi consensus-based process involving panel discussions with patients and their caregivers and clinicians.

open access
JAMA Netw Open. 2021;4(1):e2032095. doi:10.1001/jamanetworkopen.2020.32095
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PUBLIC HEALTH

Public Concern About Violence, Firearms, and the COVID-19 Pandemic in California

This survey study describes individuals’ concerns regarding violence in the context of the coronavirus disease 2019 (COVID-19) pandemic, experiences of pandemic-related unfair treatment, prevalence of and reasons for firearm acquisition, and changes in firearm storage practices due to the pandemic.

open access has active quiz
JAMA Netw Open. 2021;4(1):e2033484. doi:10.1001/jamanetworkopen.2020.33484
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RESEARCH LETTER PUBLIC HEALTH

Public Mobility and Social Media Attention in Response to COVID-19 in Sweden and Denmark

This ecological study evaluates the public mobility and social media attention associated with COVID-19 spread and societal interventions from February 15 to June 14, 2020, in Denmark and Sweden.

open access has active quiz
JAMA Netw Open. 2021;4(1):e2033478. doi:10.1001/jamanetworkopen.2020.33478
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RESEARCH LETTER GENETICS AND GENOMICS

Assessment of rAAVrh.74.MHCK7.micro-dystrophin Gene Therapy Using Magnetic Resonance Imaging in Children With Duchenne Muscular Dystrophy

This case-control study uses magnetic resonance imaging and spectroscopy to evaluate the association between treatment with recombinant adeno-associated virus serotype rh74 (rAAVrh74) and muscle quality in children with Duchenne muscular dystrophy.

open access
JAMA Netw Open. 2021;4(1):e2031851. doi:10.1001/jamanetworkopen.2020.31851
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JAMA Network Open Masthead

JAMA Network Open

open access
JAMA Netw Open. 2021;4(1):e2035535. doi:10.1001/jamanetworkopen.2020.35535
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