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Year

Day

February 25, 2021
Original Investigation

Assessment of Clinical Benefit of Integrative Genomic Profiling in Advanced Solid Tumors

Abstract Full Text
open access
JAMA Oncol. Published online February 25, 2021. doi:10.1001/jamaoncol.2020.7987

This cohort study assesses which patients with advanced solid tumors derive the greatest clinical benefit from next-generation sequencing.

Association of Risk-Reducing Salpingo-Oophorectomy With Breast Cancer Risk in Women With BRCA1 and BRCA2 Pathogenic Variants

Abstract Full Text
JAMA Oncol. Published online February 25, 2021. doi:10.1001/jamaoncol.2020.7995

This case series uses data from 876 families with BRCA1 and BRCA2 variants from the Breast Cancer Family Registry to assess whether risk-reducing salpingo-oophorectomy is associated with a reduction in breast cancer risk for women carrying these pathogenic variants.

Review

Current Treatment Strategies and Future Directions for Extrapulmonary Neuroendocrine Carcinomas: A Review

Abstract Full Text
JAMA Oncol. Published online February 25, 2021. doi:10.1001/jamaoncol.2020.8072

This review addresses the increasing knowledge on tumor biology and neuroendocrine differentiation of other malignant tumors, the current standard of care, and developments in new treatments for small cell lung cancer and extrapulmonary neuroendocrine carcinomas.

Viewpoint

Contribution of Early Clinical Benefit End Points to Decreased Lung Cancer Mortality Rates

Abstract Full Text
JAMA Oncol. Published online February 25, 2021. doi:10.1001/jamaoncol.2020.8090

This Viewpoint discusses how the use of novel therapeutics may have contributed to the decline in non–small cell lung cancer mortality rates.

Editorial

Precision Medicine in Oncology—Toward the Integrated Targeting of Somatic and Germline Genomic Aberrations

Abstract Full Text
JAMA Oncol. Published online February 25, 2021. doi:10.1001/jamaoncol.2020.7988
Comment & Response

Adjuvant Chemotherapy in Patients With Early-Stage Non–Small Cell Lung Cancer

Abstract Full Text
JAMA Oncol. Published online February 25, 2021. doi:10.1001/jamaoncol.2020.8186

Adjuvant Chemotherapy in Patients With Early-Stage Non–Small Cell Lung Cancer

Abstract Full Text
JAMA Oncol. Published online February 25, 2021. doi:10.1001/jamaoncol.2020.8189

Adjuvant Chemotherapy in Patients With Early-Stage Non–Small Cell Lung Cancer—Reply

Abstract Full Text
JAMA Oncol. Published online February 25, 2021. doi:10.1001/jamaoncol.2020.8194
Correction

Errors in Table 2

Abstract Full Text
free access
JAMA Oncol. Published online February 25, 2021. doi:10.1001/jamaoncol.2021.0158
February 18, 2021
Original Investigation

Association of Bone Metastatic Burden With Survival Benefit From Prostate Radiotherapy in Patients With Newly Diagnosed Metastatic Prostate Cancer: A Secondary Analysis of a Randomized Clinical Trial

Abstract Full Text
open access
JAMA Oncol. Published online February 18, 2021. doi:10.1001/jamaoncol.2020.7857

This exploratory analysis of a randomized clinical trial evaluates the association of bone metastasis count and location with survival benefit from prostate radiotherapy in patients with newly diagnosed metastatic prostate cancer.

Brief Report

Response Rates to Anti–PD-1 Immunotherapy in Microsatellite-Stable Solid Tumors With 10 or More Mutations per Megabase

Abstract Full Text
has audio
JAMA Oncol. Published online February 18, 2021. doi:10.1001/jamaoncol.2020.7684

This cohort study examines the performance of a universal definition of high tumor mutational burden in an independent cohort of patients with solid tumors treated with immune checkpoint inhibitors.

Association of Immunophenotype With Pathologic Complete Response to Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer: A Secondary Analysis of the BrighTNess Phase 3 Randomized Clinical Trial

Abstract Full Text
JAMA Oncol. Published online February 18, 2021. doi:10.1001/jamaoncol.2020.7310

This prespecified secondary analysis of a phase 3 randomized clinical trial evaluated the association of molecular subtype, tumor proliferation, and immunophenotype with standard neoadjuvant chemotherapy alone vs with carboplatin added for 482 patients with stages II to III triple-negative breast cancer.

Research Letter

Financial Burden of Lymphedema Hospitalizations in the United States

Abstract Full Text
JAMA Oncol. Published online February 18, 2021. doi:10.1001/jamaoncol.2020.7891

This cohort study uses data from the Healthcare Cost and Utilization Project Inpatient Sample to identify factors associated with high costs incurred during lymphedema-related hospitalizations in adults.

JAMA Oncology Clinical Challenge

Asymptomatic Purpuric Eruption on the Scalp of a Middle-aged Man

Abstract Full Text
has active quiz
JAMA Oncol. Published online February 18, 2021. doi:10.1001/jamaoncol.2020.6773

A man in his 60s with chronic lymphocytic leukemia presents with purpuric rash on his scalp. What is your diagnosis?

Invited Commentary

More Answers and More Questions About Radiotherapy for Metastatic Prostate Cancer

Abstract Full Text
JAMA Oncol. Published online February 18, 2021. doi:10.1001/jamaoncol.2020.7708
Poetry and Oncology

Book Club

Abstract Full Text
JAMA Oncol. Published online February 18, 2021. doi:10.1001/jamaoncol.2020.8014
Comment & Response

Caution With Routine Use of Daratumumab for Newly Diagnosed High-Risk Multiple Myeloma

Abstract Full Text
JAMA Oncol. Published online February 18, 2021. doi:10.1001/jamaoncol.2020.8008

Caution With Routine Use of Daratumumab for Newly Diagnosed High-Risk Multiple Myeloma—Reply

Abstract Full Text
JAMA Oncol. Published online February 18, 2021. doi:10.1001/jamaoncol.2020.8020
Correction

Data Errors in the Results

Abstract Full Text
free access
JAMA Oncol. Published online February 18, 2021. doi:10.1001/jamaoncol.2021.0005
February 11, 2021
Original Investigation

Validation of a 22-Gene Genomic Classifier in Patients With Recurrent Prostate Cancer: An Ancillary Study of the NRG/RTOG 9601 Randomized Clinical Trial

Abstract Full Text
JAMA Oncol. Published online February 11, 2021. doi:10.1001/jamaoncol.2020.7671

This ancillary study of the NRG/RTOG 9601 randomized clinical trial assesses the validity of a genomic classifier to estimate the risk of distant metastasis after radical prostatectomy in patients with prostate cancer.

Population-Based Prostate Cancer Screening With Magnetic Resonance Imaging or Ultrasonography: The IP1-PROSTAGRAM Study

Abstract Full Text
open access
JAMA Oncol. Published online February 11, 2021. doi:10.1001/jamaoncol.2020.7456

This cohort study of men undergoing prostate cancer testing compares the performance of prostate-specific antigen testing, magnetic resonance imaging, and ultrasonography as screening tests for prostate cancer.

Viewpoint

Pragmatic Solutions to Counteract the Regressive Effects of the COVID-19 Pandemic for Women in Academic Oncology

Abstract Full Text
free access has active quiz
JAMA Oncol. Published online February 11, 2021. doi:10.1001/jamaoncol.2020.7681

This Viewpoint describes how pandemic-related disruptions may adversely effect progress toward a gender-balanced workforce in academic oncology and offers possible solutions to mitigate the problem in this specialty.

Invited Commentary

Deciphering Genomic Risk in Prostate Cancer—Ready for Prime Time

Abstract Full Text
JAMA Oncol. Published online February 11, 2021. doi:10.1001/jamaoncol.2020.7579

Community-Based Screening for Prostate Cancer: A Role for Magnetic Resonance Imaging?

Abstract Full Text
JAMA Oncol. Published online February 11, 2021. doi:10.1001/jamaoncol.2020.7294
Comment & Response

Evaluation of Efficacy and Safety of Nab-Paclitaxel vs Paclitaxel in Platinum-Refractory Metastatic Urothelial Cancer

Abstract Full Text
JAMA Oncol. Published online February 11, 2021. doi:10.1001/jamaoncol.2020.8005

Evaluation of Efficacy and Safety of Nab-Paclitaxel vs Paclitaxel in Platinum-Refractory Metastatic Urothelial Cancer—Reply

Abstract Full Text
JAMA Oncol. Published online February 11, 2021. doi:10.1001/jamaoncol.2020.8017
February 4, 2021
Original Investigation

Efficacy of Endocrine Therapy for the Treatment of Breast Cancer in Men: Results from the MALE Phase 2 Randomized Clinical Trial

Abstract Full Text
JAMA Oncol. Published online February 4, 2021. doi:10.1001/jamaoncol.2020.7442

This randomized, multicenter clinical trial assesses changes in estradiol levels in male patients with hormone receptor–positive breast cancer after treatment with aromatase inhibitor plus gonadotropin-releasing hormone analogue, with gonadotropin-releasing hormone analogue plus tamoxifen, or with tamoxifen alone.

Comparison of Multiparametric Magnetic Resonance Imaging–Targeted Biopsy With Systematic Transrectal Ultrasonography Biopsy for Biopsy-Naive Men at Risk for Prostate Cancer: A Phase 3 Randomized Clinical Trial

Abstract Full Text
JAMA Oncol. Published online February 4, 2021. doi:10.1001/jamaoncol.2020.7589

This randomized clinical trial compares magnetic resonance imaging with targeted biopsy with systematic biopsy for the diagnosis of clinically significant prostate cancer.

Brief Report

Updating Reports of Phase 3 Clinical Trials for Cancer

Abstract Full Text
JAMA Oncol. Published online February 4, 2021. doi:10.1001/jamaoncol.2020.6968

This study evaluates the proportion of phase 3 randomized clinical trials for cancer that are updated and the factors that are associated with updating them and, for updated trials, compares initial and updated results.

Viewpoint

Why Not Adore ADAURA?—The Trial We Need vs the Trial We Got

Abstract Full Text
JAMA Oncol. Published online February 4, 2021. doi:10.1001/jamaoncol.2020.6752

This Viewpoint explores the application of the results of the ADAURA trial.

Adjuvant Targeted Therapy for Patients With Epidermal Growth Factor Receptor–Mutant Lung Cancer

Abstract Full Text
JAMA Oncol. Published online February 4, 2021. doi:10.1001/jamaoncol.2020.6755

This Viewpoint discusses the benefits of using adjuvant targeted therapy in earlier stages of cancer based on multiple randomized trials with promising results.

Invited Commentary

Choosing the Right Diagnostic Pathway in Biopsy-Naive Patients With Suspected Prostate Cancer

Abstract Full Text
JAMA Oncol. Published online February 4, 2021. doi:10.1001/jamaoncol.2020.7578
Comment & Response

Quantifying the Long-term Survival Benefit of Pembrolizumab for Patients With Advanced Gastric Cancer

Abstract Full Text
JAMA Oncol. Published online February 4, 2021. doi:10.1001/jamaoncol.2020.8002

Quantifying the Long-term Survival Benefit of Pembrolizumab for Patients With Advanced Gastric Cancer—Reply

Abstract Full Text
JAMA Oncol. Published online February 4, 2021. doi:10.1001/jamaoncol.2020.8011
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