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This cohort study assesses which patients with advanced solid tumors derive the greatest clinical benefit from next-generation sequencing.

This case series uses data from 876 families with BRCA1 and BRCA2 variants from the Breast Cancer Family Registry to assess whether risk-reducing salpingo-oophorectomy is associated with a reduction in breast cancer risk for women carrying these pathogenic variants.

This review addresses the increasing knowledge on tumor biology and neuroendocrine differentiation of other malignant tumors, the current standard of care, and developments in new treatments for small cell lung cancer and extrapulmonary neuroendocrine carcinomas.

This Viewpoint discusses how the use of novel therapeutics may have contributed to the decline in non–small cell lung cancer mortality rates.

This exploratory analysis of a randomized clinical trial evaluates the association of bone metastasis count and location with survival benefit from prostate radiotherapy in patients with newly diagnosed metastatic prostate cancer.

This cohort study examines the performance of a universal definition of high tumor mutational burden in an independent cohort of patients with solid tumors treated with immune checkpoint inhibitors.

This prespecified secondary analysis of a phase 3 randomized clinical trial evaluated the association of molecular subtype, tumor proliferation, and immunophenotype with standard neoadjuvant chemotherapy alone vs with carboplatin added for 482 patients with stages II to III triple-negative breast cancer.

This cohort study uses data from the Healthcare Cost and Utilization Project Inpatient Sample to identify factors associated with high costs incurred during lymphedema-related hospitalizations in adults.

A man in his 60s with chronic lymphocytic leukemia presents with purpuric rash on his scalp. What is your diagnosis?

This ancillary study of the NRG/RTOG 9601 randomized clinical trial assesses the validity of a genomic classifier to estimate the risk of distant metastasis after radical prostatectomy in patients with prostate cancer.

This cohort study of men undergoing prostate cancer testing compares the performance of prostate-specific antigen testing, magnetic resonance imaging, and ultrasonography as screening tests for prostate cancer.

This Viewpoint describes how pandemic-related disruptions may adversely effect progress toward a gender-balanced workforce in academic oncology and offers possible solutions to mitigate the problem in this specialty.

This randomized, multicenter clinical trial assesses changes in estradiol levels in male patients with hormone receptor–positive breast cancer after treatment with aromatase inhibitor plus gonadotropin-releasing hormone analogue, with gonadotropin-releasing hormone analogue plus tamoxifen, or with tamoxifen alone.

This randomized clinical trial compares magnetic resonance imaging with targeted biopsy with systematic biopsy for the diagnosis of clinically significant prostate cancer.

This study evaluates the proportion of phase 3 randomized clinical trials for cancer that are updated and the factors that are associated with updating them and, for updated trials, compares initial and updated results.

This Viewpoint explores the application of the results of the ADAURA trial.

This Viewpoint discusses the benefits of using adjuvant targeted therapy in earlier stages of cancer based on multiple randomized trials with promising results.