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Day

February 25, 2021
Viewpoint

What Is Just the Right Amount of Anti–Vascular Endothelial Growth Factor Treatment for Diabetic Macular Edema?Protocol V and the Goldilocks Principle

Abstract Full Text
JAMA Ophthalmol. Published online February 25, 2021. doi:10.1001/jamaophthalmol.2021.0013

This Viewpoint asks what is the maximum that can be done to prevent vision loss in patients with diabetic macular edema.

Original Investigation

Early Experience With Brolucizumab Treatment of Neovascular Age-Related Macular Degeneration

Abstract Full Text
JAMA Ophthalmol. Published online February 25, 2021. doi:10.1001/jamaophthalmol.2020.7085

This case series reports clinical outcomes after intravitreous injection of brolucizumab, 6 mg, for neovascular age-related macular degeneration.

JAMA Ophthalmology Clinical Challenge

Unilateral Hypopyon in an Elderly Man With Dementia

Abstract Full Text
has active quiz
JAMA Ophthalmol. Published online February 25, 2021. doi:10.1001/jamaophthalmol.2020.4633

An elderly man with a history of Philadelphia chromosome–positive acute lymphocytic leukemia, diabetes, and dementia presented with decreased visual acuity and hypopyon in his right eye. What would you do next?

Correction

Replacement of Nonauthor Collaborator Names

Abstract Full Text
free access
JAMA Ophthalmol. Published online February 25, 2021. doi:10.1001/jamaophthalmol.2021.0124
February 18, 2021
Original Investigation

Tuberculosis Exposure With Risk of Behçet Disease Among Patients With Uveitis

Abstract Full Text
JAMA Ophthalmol. Published online February 18, 2021. doi:10.1001/jamaophthalmol.2020.6985

This mendelian randomization and cohort study evaluated associations of tuberculosis with several noninfectious uveitis conditions, particularly Behçet disease, in cohorts in China and Japan, including a subgroup given T-SPOT.TB assays.

Predicting Edema Resolution After Descemet Membrane Endothelial Keratoplasty for Fuchs Dystrophy Using Scheimpflug Tomography

Abstract Full Text
JAMA Ophthalmol. Published online February 18, 2021. doi:10.1001/jamaophthalmol.2020.6994

This prognostic study develops a predictive model in which Scheimpflug tomographic imaging is used to evaluate edema resolution after Descemet membrane endothelial keratoplasty in patients with advanced Fuchs dystrophy.

Discordance Rate Among Bilateral Simultaneous and Sequential Temporal Artery Biopsies in Giant Cell Arteritis: Role of Frozen Sectioning Based on the Mayo Clinic Experience

Abstract Full Text
JAMA Ophthalmol. Published online February 18, 2021. doi:10.1001/jamaophthalmol.2020.6896

This cohort study evaluates the sensitivity and specificity of temporal artery biopsy frozen vs permanent section pathology results for giant cell arteritis and determines the discordance rate of bilateral temporal artery biopsies.

Prevalence and Factors Associated With Eyeglass Wear Compliance Among Preschoolers From Low-Income Families in San Francisco, California

Abstract Full Text
JAMA Ophthalmol. Published online February 18, 2021. doi:10.1001/jamaophthalmol.2020.7053

This cross-sectional study assesses the prevalence and factors associated with eyeglass wear compliance for a school year among preschool children who have a failed vision screening, are from low-income families, and receive eyeglasses through the See Well to Learn program.

Invited Commentary

Toward a Paradigm Shift in the Therapeutic Approach to Fuchs Endothelial Corneal Dystrophy

Abstract Full Text
JAMA Ophthalmol. Published online February 18, 2021. doi:10.1001/jamaophthalmol.2020.7041

Is It Always Better to Get Faster Results in Temporal Artery Biopsies?

Abstract Full Text
JAMA Ophthalmol. Published online February 18, 2021. doi:10.1001/jamaophthalmol.2020.6895
JAMA Ophthalmology Clinical Challenge

Unilateral Frosted Branch Angiitis in a Patient With Immunosuppression

Abstract Full Text
has active quiz
JAMA Ophthalmol. Published online February 18, 2021. doi:10.1001/jamaophthalmol.2020.4684

A 49-year-old man presents with acute unilateral painless vision loss, antisynthetase syndrome, fever, and interstitial lung disease. What would you do next?

February 12, 2021
Original Investigation

A Global Assessment of Eye Health and Quality of Life: A Systematic Review of Systematic Reviews

Abstract Full Text
open access
JAMA Ophthalmol. Published online February 12, 2021. doi:10.1001/jamaophthalmol.2021.0146

This cross-sectional study examines the association between vision impairment or eye disease and quality of life and the outcome of ophthalmic interventions on quality of life globally and across the life span.

February 11, 2021
Original Investigation

Assessment of Trends in the Incidence Rates of Central Retinal Artery Occlusion in Korea From 2002 to 2015

Abstract Full Text
JAMA Ophthalmol. Published online February 11, 2021. doi:10.1001/jamaophthalmol.2020.6860

This cohort study uses data from the Korean National Health Insurance Service database from 2002 to 2015 to estimate temporal trends in the incidence rates of central retinal artery occlusion among residents of Korea.

JAMA Ophthalmology Clinical Challenge

Nonclearing Corneal Edema After Phacoemulsification and Intraocular Lens Implantation

Abstract Full Text
has active quiz
JAMA Ophthalmol. Published online February 11, 2021. doi:10.1001/jamaophthalmol.2020.4660

An 82-year-old man presents with a history of bilateral nuclear sclerotic cataracts and blurred vision in the right eye after cataract extraction 8 weeks earlier. On examination, his best-corrected visual acuity is 20/80 OD and 20/20 OS with a few guttate in the left eye, and central corneal thickness is 957 and 547 μm in the right and left eyes, respectively. What would you do next?

Comment & Response

Do Racial/Ethnic Disparities in Rates of Enucleation for Uveal Melanoma Indicate Poor Quality of Care or Financial Obstacles?

Abstract Full Text
JAMA Ophthalmol. Published online February 11, 2021. doi:10.1001/jamaophthalmol.2020.6828

Do Racial/Ethnic Disparities in Rates of Enucleation for Uveal Melanoma Indicate Poor Quality of Care or Financial Obstacles?—Reply

Abstract Full Text
JAMA Ophthalmol. Published online February 11, 2021. doi:10.1001/jamaophthalmol.2020.6831
February 4, 2021
Original Investigation

Opportunities to Reduce Potential Bias in Ophthalmic Cost-Utility Analysis

Abstract Full Text
JAMA Ophthalmol. Published online February 4, 2021. doi:10.1001/jamaophthalmol.2020.6591

This economic evaluation assesses whether use of nonpatient vision utilities and a maximum limit model constraining vision utility gain to the systemic comorbidity utility level biases against ophthalmic cost-utility outcomes among patients with neovascular age-related macular degeneration and cataract.

Longitudinal Assessment of Retinal Thinning in Adults With and Without Sickle Cell Retinopathy Using Spectral-Domain Optical Coherence Tomography

Abstract Full Text
has audio
JAMA Ophthalmol. Published online February 4, 2021. doi:10.1001/jamaophthalmol.2020.6525

This case-control study assesses the rates of retinal thinning in adults with and without sickle cell retinopathy using spectral-domain optical coherence tomography and examines ocular and systemic risk factors associated with retinal thinning.

Invited Commentary

Calculating Utility Gain by Different Methods for the Treatment of Cataract or Neovascular Age-Related Macular Degeneration: What Are the Consequences?

Abstract Full Text
JAMA Ophthalmol. Published online February 4, 2021. doi:10.1001/jamaophthalmol.2020.6584

Sickle Cell Disease and the Eye—Everything Old Is New Again

Abstract Full Text
JAMA Ophthalmol. Published online February 4, 2021. doi:10.1001/jamaophthalmol.2020.6526
JAMA Ophthalmology Clinical Challenge

White Macula After Pars Plana Vitrectomy in a 71-Year-Old Woman

Abstract Full Text
has active quiz
JAMA Ophthalmol. Published online February 4, 2021. doi:10.1001/jamaophthalmol.2020.4616

Three weeks after uneventful pars plana vitrectomy of the right eye for vitreomacular traction, a 71-year-old woman presents with a painless central scotoma and worsening floaters. Optical coherence tomography shows atrophy, full-thickness hyperreflectivity, and a residual epiretinal membrane. What would you do next?

Comment & Response

Long-term Macular Effects of Pentosan Polysulfate Sodium Exposure Uncertain—Let’s Not Jump to Conclusions

Abstract Full Text
JAMA Ophthalmol. Published online February 4, 2021. doi:10.1001/jamaophthalmol.2020.6615

Long-term Macular Effects of Pentosan Polysulfate Sodium Exposure Uncertain—Let’s Not Jump to Conclusions—Reply

Abstract Full Text
JAMA Ophthalmol. Published online February 4, 2021. doi:10.1001/jamaophthalmol.2020.6618
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